Protein Kinase, X-Linked (PRKX)

PKX1; cAMP-dependent protein kinase catalytic subunit PRKX

SPN	P430
HGNC	9441
MGI	1309999
PubMed	22020623
RGD	1564076
UniProt	P51817

PKX1 appeared to encode a novel type of protein kinase that is related to the catalytic subunit of cAMP-dependent protein kinases and has striking homology to the DC2 protein kinase of Drosophila melanogaster. PKX1 is part of a family of at least 4 genes or pseudogenes, of which 3 map to the human sex chromosomes. In contrast to all other genes from the X-specific region of Xp22.3, PKX1 has a homolog on Yp (PRKY) rather than Yq. This suggests that the single pericentric inversion event hypothesized to have occurred during primate evolution is not sufficient to explain the present X/Y homology pattern of Xp22.3.This suggests that the PKX1 gene, besides harboring a previously described hotspot for illegitimate Xp/Yp recombination, contains additional sequences which predispose the X chromosome to breakage events.

Reference

"The human protein kinase gene PKX1 on Xp22.3 displays Xp/Yp homology and is a site of chromosomal instability."
Hum. Mol. Genet. 4:869-878(1995) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females."
Hum. Mol. Genet. 6:1985-1989(1997) [PubMed] [Europe PMC] [Abstract]

"A lineage-specific protein kinase crucial for myeloid maturation."
Proc. Natl. Acad. Sci. U.S.A. 95:15412-15417(1998) [PubMed] [Europe PMC] [Abstract]

"PrKX is a novel catalytic subunit of the cAMP-dependent protein kinase regulated by the regulatory subunit type I."
J. Biol. Chem. 274:5370-5378(1999) [PubMed] [Europe PMC] [Abstract]

"PRKX, a phylogenetically and functionally distinct cAMP-dependent protein kinase, activates renal epithelial cell migration and morphogenesis."
Proc. Natl. Acad. Sci. U.S.A. 99:9260-9265(2002) [PubMed] [Europe PMC] [Abstract]

"Protein kinase X activates ureteric bud branching morphogenesis in developing mouse metanephric kidney."
J. Am. Soc. Nephrol. 16:3543-3552(2005) [PubMed] [Europe PMC] [Abstract]

"Profiles of PrKX expression in developmental mouse embryo and human tissues."
J. Histochem. Cytochem. 53:1003-1009(2005) [PubMed] [Europe PMC] [Abstract]

"Smad6 is a protein kinase X phosphorylation substrate and is required for HL-60 cell differentiation."
Oncogene 25:4086-4098(2006) [PubMed] [Europe PMC] [Abstract]

"Protein kinase X (PRKX) can rescue the effects of polycystic kidney disease-1 gene (PKD1) deficiency."
Biochim. Biophys. Acta 1782:1-9(2008) [PubMed] [Europe PMC] [Abstract]

"Protein kinase-X interacts with Pin-1 and Polycystin-1 during mouse kidney development."
Kidney Int. 76:54-62(2009) [PubMed] [Europe PMC] [Abstract]

"Regulation of cAMP-dependent protein kinases: the human protein kinase X (PrKX) reveals the role of the catalytic subunit alphaH-alphaI loop."
J. Biol. Chem. 285:35910-35918(2010) [PubMed] [Europe PMC] [Abstract]

"PRKX critically regulates endothelial cell proliferation, migration, and vascular-like structure formation."
Dev. Biol. 356:475-485(2011) [PubMed] [Europe PMC] [Abstract]

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]