Periostin (POSTN)

OSF-2; PDLPOSTN; PN; Osteoblast Specific Factor 2

SPN	P396
HGNC	16953
MGI	1926321
PubMed	8363580
RGD	1305285
UniProt	Q15063
Wiki	Periostin

By screening human placenta and osteosarcoma cDNA libraries with mouse Postn as probe, they cloned 2 variants of human POSTN. One variant encodes a deduced 779-amino acid protein with an apparent molecular mass of 87.0 kD, and the other encodes a deduced 836-amino acid protein with an apparent molecular mass of 93.3 kD. POSTN contains a typical signal sequence, followed by a cysteine-rich domain, a 4-fold repeat structure of about 150 amino acids, and a C-terminal domain. Mouse and human POSTN share 89.2% amino acid identity overall and 90.1% identity in their mature forms. Northern blot analysis of a mouse osteoblastic cell line detected a 3.4-kb Postn transcript. RNA dot blot analysis detected expression of Postn in primary mouse osteoblasts and in lung, but not in any other tissues examined.

Reference

"Osteoblast-specific factor 2: cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I."
Biochem. J. 294:271-278(1993) [PubMed] [Europe PMC] [Abstract]

Ref.1"Osteoblast-specific factor 2: cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I."
Biochem. J. 294:271-278(1993) [PubMed] [Europe PMC] [Abstract]

Ref.1"Osteoblast-specific factor 2: cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I."
Biochem. J. 294:271-278(1993) [PubMed] [Europe PMC] [Abstract]

"Periostin secreted by epithelial ovarian carcinoma is a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins and promotes cell motility."
Cancer Res. 62:5358-5364(2002) [PubMed] [Europe PMC] [Abstract]

"Novel isoforms of periostin expressed in the human thyroid."
Jpn. Clin. Med. 1:13-20(2010) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 13."
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Serum level of the periostin, a homologue of an insect cell adhesion molecule, as a prognostic marker in nonsmall cell lung carcinomas."
Cancer 92:843-848(2001) [PubMed] [Europe PMC] [Abstract]

Erratum
Cancer 95:2580-2580(2002)

"Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression."
Mol. Cell. Biol. 24:3992-4003(2004) [PubMed] [Europe PMC] [Abstract]

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

"Periostin, a member of a novel family of vitamin K-dependent proteins, is expressed by mesenchymal stromal cells."
J. Biol. Chem. 283:17991-18001(2008) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]