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Prenylcysteine Oxidase 1 (PCYOX1)

PCL1; Prenylcysteine lyase

Prenylcysteine is released during the degradation of prenylated proteins. PCYOX1 catalyzes the degradation of prenylcysteine to yield free cysteines and a hydrophobic isoprenoid product .
The deduced 505-amino acid protein contains a predicted signal sequence, several transmembrane regions, and potential N-glycosylation sites. Northern blot analysis detected a 6-kb transcript in heart, kidney, liver, colon, placenta, skeletal muscle, and pancreas, with low expression in brain and no expression in spleen. The 3-prime untranslated region contains several SINEs, including Alu and MIR sequences. The predicted protein has 506 amino acids. RT-PCR ELISA detected high to moderate expression in all adult and fetal human tissues and all specific brain regions tested.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP307Hu01 Recombinant Prenylcysteine Oxidase 1 (PCYOX1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP307Hu01 Monoclonal Antibody to Prenylcysteine Oxidase 1 (PCYOX1) WB; IHC; ICC; IP.
PAP307Hu01 Polyclonal Antibody to Prenylcysteine Oxidase 1 (PCYOX1) WB; IHC; ICC; IF.
Assay Kits CLP307Hu01 CLIA Kit for Prenylcysteine Oxidase 1 (PCYOX1) CLIA assay for Antigen Detection
ELP307Hu01 ELISA Kit for Prenylcysteine Oxidase 1 (PCYOX1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP307Mu01 Recombinant Prenylcysteine Oxidase 1 (PCYOX1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP307Mu01 Monoclonal Antibody to Prenylcysteine Oxidase 1 (PCYOX1) WB; IHC; ICC; IP.
PAP307Mu01 Polyclonal Antibody to Prenylcysteine Oxidase 1 (PCYOX1) WB; IHC; ICC; IF.
Assay Kits CLP307Mu01 CLIA Kit for Prenylcysteine Oxidase 1 (PCYOX1) CLIA assay for Antigen Detection
ELP307Mu01 ELISA Kit for Prenylcysteine Oxidase 1 (PCYOX1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP307Ra01 Recombinant Prenylcysteine Oxidase 1 (PCYOX1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP307Ra01 Monoclonal Antibody to Prenylcysteine Oxidase 1 (PCYOX1) WB; IHC; ICC; IP.
PAP307Ra01 Polyclonal Antibody to Prenylcysteine Oxidase 1 (PCYOX1) WB; IHC; ICC; IF.
Assay Kits CLP307Ra01 CLIA Kit for Prenylcysteine Oxidase 1 (PCYOX1) CLIA assay for Antigen Detection
ELP307Ra01 ELISA Kit for Prenylcysteine Oxidase 1 (PCYOX1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP307Ca01 Recombinant Prenylcysteine Oxidase 1 (PCYOX1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP307Ca01 Monoclonal Antibody to Prenylcysteine Oxidase 1 (PCYOX1) WB; IHC; ICC; IP.
PAP307Ca01 Polyclonal Antibody to Prenylcysteine Oxidase 1 (PCYOX1) WB; IHC; ICC; IF.
Assay Kits CLP307Ca01 CLIA Kit for Prenylcysteine Oxidase 1 (PCYOX1) CLIA assay for Antigen Detection
ELP307Ca01 ELISA Kit for Prenylcysteine Oxidase 1 (PCYOX1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP307Po01 Recombinant Prenylcysteine Oxidase 1 (PCYOX1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP307Po01 Monoclonal Antibody to Prenylcysteine Oxidase 1 (PCYOX1) WB; IHC; ICC; IP.
PAP307Po01 Polyclonal Antibody to Prenylcysteine Oxidase 1 (PCYOX1) WB; IHC; ICC; IF.
Assay Kits CLP307Po01 CLIA Kit for Prenylcysteine Oxidase 1 (PCYOX1) CLIA assay for Antigen Detection
ELP307Po01 ELISA Kit for Prenylcysteine Oxidase 1 (PCYOX1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP307Bo01 Recombinant Prenylcysteine Oxidase 1 (PCYOX1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP307Bo01 Monoclonal Antibody to Prenylcysteine Oxidase 1 (PCYOX1) WB; IHC; ICC; IP.
PAP307Bo01 Polyclonal Antibody to Prenylcysteine Oxidase 1 (PCYOX1) WB; IHC; ICC; IF.
Assay Kits CLP307Bo01 CLIA Kit for Prenylcysteine Oxidase 1 (PCYOX1) CLIA assay for Antigen Detection
ELP307Bo01 ELISA Kit for Prenylcysteine Oxidase 1 (PCYOX1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP307Rb01 Recombinant Prenylcysteine Oxidase 1 (PCYOX1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP307Rb01 Monoclonal Antibody to Prenylcysteine Oxidase 1 (PCYOX1) WB; IHC; ICC; IP.
PAP307Rb01 Polyclonal Antibody to Prenylcysteine Oxidase 1 (PCYOX1) WB; IHC; ICC; IF.
Assay Kits CLP307Rb01 CLIA Kit for Prenylcysteine Oxidase 1 (PCYOX1) CLIA assay for Antigen Detection
ELP307Rb01 ELISA Kit for Prenylcysteine Oxidase 1 (PCYOX1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP307Mo01 Recombinant Prenylcysteine Oxidase 1 (PCYOX1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP307Mo01 Monoclonal Antibody to Prenylcysteine Oxidase 1 (PCYOX1) WB; IHC; ICC; IP.
PAP307Mo01 Polyclonal Antibody to Prenylcysteine Oxidase 1 (PCYOX1) WB; IHC; ICC; IF.
Assay Kits CLP307Mo01 CLIA Kit for Prenylcysteine Oxidase 1 (PCYOX1) CLIA assay for Antigen Detection
ELP307Mo01 ELISA Kit for Prenylcysteine Oxidase 1 (PCYOX1) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Cloning, expression, and cellular localization of a human prenylcysteine lyase."
J. Biol. Chem. 274:35802-35808(1999) [PubMed] [Europe PMC] [Abstract]

"Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]