Nicotinamide-N-Methyltransferase (NNMT)
Nicotinamide N-methyltransferase (EC 2.1.1.1) catalyzes the N-methylation of nicotinamide and other pyridines. Human liver NNMT activity has a bimodal frequency distribution, an observation that raises the possibility that this enzyme activity may be regulated by a genetic polymorphism. Such a polymorphism could have functional implications for individual differences in drug and xenobiotic toxicity.
Transcription initiation for the NNMT gene occurred 105 to 109 bp 5-prime upstream from the cDNA translation initiation codon, as determined by both primer extension and 5-prime rapid amplification of cDNA ends. By fluorescence in situ hybridization, they mapped NNMT to 11q23.1.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP206Hu01 | Recombinant Nicotinamide-N-Methyltransferase (NNMT) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP206Hu01 | Monoclonal Antibody to Nicotinamide-N-Methyltransferase (NNMT) | WB; IHC; ICC; IP. |
| PAP206Hu01 | Polyclonal Antibody to Nicotinamide-N-Methyltransferase (NNMT) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP206Hu01 | CLIA Kit for Nicotinamide-N-Methyltransferase (NNMT) | CLIA assay for Antigen Detection |
| ELP206Hu01 | ELISA Kit for Nicotinamide-N-Methyltransferase (NNMT) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP206Mu01 | Recombinant Nicotinamide-N-Methyltransferase (NNMT) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP206Mu01 | Monoclonal Antibody to Nicotinamide-N-Methyltransferase (NNMT) | WB; IHC; ICC; IP. |
| PAP206Mu01 | Polyclonal Antibody to Nicotinamide-N-Methyltransferase (NNMT) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP206Mu01 | CLIA Kit for Nicotinamide-N-Methyltransferase (NNMT) | CLIA assay for Antigen Detection |
| ELP206Mu01 | ELISA Kit for Nicotinamide-N-Methyltransferase (NNMT) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP206Ra01 | Recombinant Nicotinamide-N-Methyltransferase (NNMT) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP206Ra01 | Monoclonal Antibody to Nicotinamide-N-Methyltransferase (NNMT) | WB; IHC; ICC; IP. |
| PAP206Ra01 | Polyclonal Antibody to Nicotinamide-N-Methyltransferase (NNMT) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP206Ra01 | CLIA Kit for Nicotinamide-N-Methyltransferase (NNMT) | CLIA assay for Antigen Detection |
| ELP206Ra01 | ELISA Kit for Nicotinamide-N-Methyltransferase (NNMT) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP206Ca01 | Recombinant Nicotinamide-N-Methyltransferase (NNMT) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP206Ca01 | Monoclonal Antibody to Nicotinamide-N-Methyltransferase (NNMT) | WB; IHC; ICC; IP. |
| PAP206Ca01 | Polyclonal Antibody to Nicotinamide-N-Methyltransferase (NNMT) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP206Ca01 | CLIA Kit for Nicotinamide-N-Methyltransferase (NNMT) | CLIA assay for Antigen Detection |
| ELP206Ca01 | ELISA Kit for Nicotinamide-N-Methyltransferase (NNMT) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP206Po01 | Recombinant Nicotinamide-N-Methyltransferase (NNMT) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP206Po01 | Monoclonal Antibody to Nicotinamide-N-Methyltransferase (NNMT) | WB; IHC; ICC; IP. |
| PAP206Po01 | Polyclonal Antibody to Nicotinamide-N-Methyltransferase (NNMT) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP206Po01 | CLIA Kit for Nicotinamide-N-Methyltransferase (NNMT) | CLIA assay for Antigen Detection |
| ELP206Po01 | ELISA Kit for Nicotinamide-N-Methyltransferase (NNMT) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP206Bo01 | Recombinant Nicotinamide-N-Methyltransferase (NNMT) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP206Bo01 | Monoclonal Antibody to Nicotinamide-N-Methyltransferase (NNMT) | WB; IHC; ICC; IP. |
| PAP206Bo01 | Polyclonal Antibody to Nicotinamide-N-Methyltransferase (NNMT) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP206Bo01 | CLIA Kit for Nicotinamide-N-Methyltransferase (NNMT) | CLIA assay for Antigen Detection |
| ELP206Bo01 | ELISA Kit for Nicotinamide-N-Methyltransferase (NNMT) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP206Rb01 | Recombinant Nicotinamide-N-Methyltransferase (NNMT) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP206Rb01 | Monoclonal Antibody to Nicotinamide-N-Methyltransferase (NNMT) | WB; IHC; ICC; IP. |
| PAP206Rb01 | Polyclonal Antibody to Nicotinamide-N-Methyltransferase (NNMT) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP206Rb01 | CLIA Kit for Nicotinamide-N-Methyltransferase (NNMT) | CLIA assay for Antigen Detection |
| ELP206Rb01 | ELISA Kit for Nicotinamide-N-Methyltransferase (NNMT) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP206Mo01 | Recombinant Nicotinamide-N-Methyltransferase (NNMT) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP206Mo01 | Monoclonal Antibody to Nicotinamide-N-Methyltransferase (NNMT) | WB; IHC; ICC; IP. |
| PAP206Mo01 | Polyclonal Antibody to Nicotinamide-N-Methyltransferase (NNMT) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP206Mo01 | CLIA Kit for Nicotinamide-N-Methyltransferase (NNMT) | CLIA assay for Antigen Detection |
| ELP206Mo01 | ELISA Kit for Nicotinamide-N-Methyltransferase (NNMT) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Human liver nicotinamide N-methyltransferase. cDNA cloning, expression, and biochemical characterization."
J. Biol. Chem. 269:14835-14840(1994) [PubMed] [Europe PMC] [Abstract]
"Human nicotinamide N-methyltransferase gene: molecular cloning, structural characterization and chromosomal localization."
Genomics 29:555-561(1995) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Human ERp29: isolation, primary structural characterisation and two-dimensional gel mapping."
Electrophoresis 21:3785-3796(2000) [PubMed] [Europe PMC] [Abstract]
"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"The crystal structure of human nicotinamide N-methyltransferase in complex with SAH."
Submitted (OCT-2006) to the PDB data bank