Neurogenin 3 (NEUROG3)

Math4B; Atoh5; ngn3; bHLHa7; Class A basic helix-loop-helix protein 7; Protein atonal homolog 5

SPN	P188
HGNC	13806
MGI	893591
PubMed	19487660
RGD	631350
UniProt	Q9Y4Z2
Wiki	NEUROG3

Neurogenin-3 is expressed in endocrine progenitor cells and is required for endocrine cell development in the pancreas and intestine. It belongs to a family of basic helix-loop-helix (bHLH) transcription factors involved in the determination of neural precursor cells in the neuroectoderm.

In pancreas and brain the major splicing isoform does not code for a protein, potentially a regulatory mechanism as overexpression of the protein causes exit from cell cycle and depletion of the progenitor pool.Expression was detectable as early as embryonic day 9 and persisted until day 14. Ngn3 was also expressed in the developing hypothalamic region and in pancreatic islet cell progenitors.

Reference

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 10."
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Mutant neurogenin-3 in congenital malabsorptive diarrhea."
N. Engl. J. Med. 355:270-280(2006) [PubMed] [Europe PMC] [Abstract]