Neudesin Neurotrophic Factor (NENF)
CIR2; SCIRP10; NDNF; SPUF; Neudesin; Cell immortalization-related protein 2; Neuron-derived neurotrophic factor; Secreted protein of unknown function
Neudesin was expressed in early development in mouse embryonic cerebral cortex in neural precursor cells. Studies in culture showed that neudesin promoted neuronal differentiation and inhibited differentiation of astrocytes.neudesin has a predicted cytochrome b5-like heme/steroid-binding domain, and determined that Fe(III)-protoporphyrin IX is required for its neurotrophic activity. An anti-neudesin antibody detected a 15.6-kD band in media from cultured Neuro2a cells and was used in experiments to confirm that the protein binds heme. In mice, in situ hybridization showed abundant expression of neudesin in developing brain and spinal cord, and RT-PCR of postnatal tissues demonstrated expression in brain, heart, lung, and kidney. The protein was expressed in neurons but not in glial cells.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP179Hu01 | Recombinant Neudesin Neurotrophic Factor (NENF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP179Hu01 | Monoclonal Antibody to Neudesin Neurotrophic Factor (NENF) | WB; IHC; ICC; IP. |
| PAP179Hu01 | Polyclonal Antibody to Neudesin Neurotrophic Factor (NENF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP179Hu01 | CLIA Kit for Neudesin Neurotrophic Factor (NENF) | CLIA assay for Antigen Detection |
| ELP179Hu01 | ELISA Kit for Neudesin Neurotrophic Factor (NENF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP179Mu01 | Recombinant Neudesin Neurotrophic Factor (NENF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP179Mu01 | Monoclonal Antibody to Neudesin Neurotrophic Factor (NENF) | WB; IHC; ICC; IP. |
| PAP179Mu01 | Polyclonal Antibody to Neudesin Neurotrophic Factor (NENF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP179Mu01 | CLIA Kit for Neudesin Neurotrophic Factor (NENF) | CLIA assay for Antigen Detection |
| ELP179Mu01 | ELISA Kit for Neudesin Neurotrophic Factor (NENF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP179Ra01 | Recombinant Neudesin Neurotrophic Factor (NENF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP179Ra01 | Monoclonal Antibody to Neudesin Neurotrophic Factor (NENF) | WB; IHC; ICC; IP. |
| PAP179Ra01 | Polyclonal Antibody to Neudesin Neurotrophic Factor (NENF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP179Ra01 | CLIA Kit for Neudesin Neurotrophic Factor (NENF) | CLIA assay for Antigen Detection |
| ELP179Ra01 | ELISA Kit for Neudesin Neurotrophic Factor (NENF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP179Ca01 | Recombinant Neudesin Neurotrophic Factor (NENF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP179Ca01 | Monoclonal Antibody to Neudesin Neurotrophic Factor (NENF) | WB; IHC; ICC; IP. |
| PAP179Ca01 | Polyclonal Antibody to Neudesin Neurotrophic Factor (NENF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP179Ca01 | CLIA Kit for Neudesin Neurotrophic Factor (NENF) | CLIA assay for Antigen Detection |
| ELP179Ca01 | ELISA Kit for Neudesin Neurotrophic Factor (NENF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP179Po01 | Recombinant Neudesin Neurotrophic Factor (NENF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP179Po01 | Monoclonal Antibody to Neudesin Neurotrophic Factor (NENF) | WB; IHC; ICC; IP. |
| PAP179Po01 | Polyclonal Antibody to Neudesin Neurotrophic Factor (NENF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP179Po01 | CLIA Kit for Neudesin Neurotrophic Factor (NENF) | CLIA assay for Antigen Detection |
| ELP179Po01 | ELISA Kit for Neudesin Neurotrophic Factor (NENF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP179Bo01 | Recombinant Neudesin Neurotrophic Factor (NENF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP179Bo01 | Monoclonal Antibody to Neudesin Neurotrophic Factor (NENF) | WB; IHC; ICC; IP. |
| PAP179Bo01 | Polyclonal Antibody to Neudesin Neurotrophic Factor (NENF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP179Bo01 | CLIA Kit for Neudesin Neurotrophic Factor (NENF) | CLIA assay for Antigen Detection |
| ELP179Bo01 | ELISA Kit for Neudesin Neurotrophic Factor (NENF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP179Rb01 | Recombinant Neudesin Neurotrophic Factor (NENF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP179Rb01 | Monoclonal Antibody to Neudesin Neurotrophic Factor (NENF) | WB; IHC; ICC; IP. |
| PAP179Rb01 | Polyclonal Antibody to Neudesin Neurotrophic Factor (NENF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP179Rb01 | CLIA Kit for Neudesin Neurotrophic Factor (NENF) | CLIA assay for Antigen Detection |
| ELP179Rb01 | ELISA Kit for Neudesin Neurotrophic Factor (NENF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP179Mo01 | Recombinant Neudesin Neurotrophic Factor (NENF) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP179Mo01 | Monoclonal Antibody to Neudesin Neurotrophic Factor (NENF) | WB; IHC; ICC; IP. |
| PAP179Mo01 | Polyclonal Antibody to Neudesin Neurotrophic Factor (NENF) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP179Mo01 | CLIA Kit for Neudesin Neurotrophic Factor (NENF) | CLIA assay for Antigen Detection |
| ELP179Mo01 | ELISA Kit for Neudesin Neurotrophic Factor (NENF) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Neudesin, a novel secreted protein with a unique primary structure and neurotrophic activity."
J. Neurosci. Res. 79:287-294(2005) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Up-regulation of CIR1/CROC1 expression upon cell immortalization and in tumor-derived human cell lines."
Oncogene 17:1321-1326(1998) [PubMed] [Europe PMC] [Abstract]
"Breast cancer proteomics by laser capture microdissection, sample pooling, 54-cm IPG IEF, and differential iodine radioisotope detection."
Electrophoresis 27:1840-1852(2006) [PubMed] [Europe PMC] [Abstract]
"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"The functional and structural characterization of a novel oncogene GIG47 involved in the breast tumorigenesis."
BMC Cancer 12:274-274(2012) [PubMed] [Europe PMC] [Abstract]