NAD Kinase (NADK)

Poly(P)/ATP NAD kinase

SPN	P158
HGNC	29831
MGI	2183149
PubMed	21517775
UniProt	O95544
Wiki	NADK

kinase (EC 2.7.1.23, NADK) is an enzyme that converts nicotinamide adenine dinucleotide (NAD⁺) into NADP⁺, through phosphorylating the NAD⁺ coenzyme. NADP⁺ is an essential coenzyme in metabolism and provides reducing power to biosynthetic processes such as fatty acid biosynthesis. The structure of the NADK from the archaean Archaeoglobus fulgidus has been determined.

The deduced 446-amino acid protein has a calculated molecular mass of 49.2 kD. Northern blot analysis detected a 3.0-kb transcript with high expression in placenta, moderate expression in brain, colon, heart, liver, kidney, lung, spleen, stomach, and testis, and low expression in small intestine. A band of 1.8 kb was detected in several tissues.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP158Hu01	Recombinant NAD Kinase (NADK)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP158Hu01	Monoclonal Antibody to NAD Kinase (NADK)	WB; IHC; ICC; IP.
Antibodies	PAP158Hu01	Polyclonal Antibody to NAD Kinase (NADK)	WB; IHC; ICC; IF.
Assay Kits	CLP158Hu01	CLIA Kit for NAD Kinase (NADK)	CLIA assay for Antigen Detection
Assay Kits	ELP158Hu01	ELISA Kit for NAD Kinase (NADK)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP158Mu01	Recombinant NAD Kinase (NADK)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP158Mu01	Monoclonal Antibody to NAD Kinase (NADK)	WB; IHC; ICC; IP.
Antibodies	PAP158Mu01	Polyclonal Antibody to NAD Kinase (NADK)	WB; IHC; ICC; IF.
Assay Kits	CLP158Mu01	CLIA Kit for NAD Kinase (NADK)	CLIA assay for Antigen Detection
Assay Kits	ELP158Mu01	ELISA Kit for NAD Kinase (NADK)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP158Ra01	Recombinant NAD Kinase (NADK)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP158Ra01	Monoclonal Antibody to NAD Kinase (NADK)	WB; IHC; ICC; IP.
Antibodies	PAP158Ra01	Polyclonal Antibody to NAD Kinase (NADK)	WB; IHC; ICC; IF.
Assay Kits	CLP158Ra01	CLIA Kit for NAD Kinase (NADK)	CLIA assay for Antigen Detection
Assay Kits	ELP158Ra01	ELISA Kit for NAD Kinase (NADK)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP158Ca01	Recombinant NAD Kinase (NADK)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP158Ca01	Monoclonal Antibody to NAD Kinase (NADK)	WB; IHC; ICC; IP.
Antibodies	PAP158Ca01	Polyclonal Antibody to NAD Kinase (NADK)	WB; IHC; ICC; IF.
Assay Kits	CLP158Ca01	CLIA Kit for NAD Kinase (NADK)	CLIA assay for Antigen Detection
Assay Kits	ELP158Ca01	ELISA Kit for NAD Kinase (NADK)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP158Po01	Recombinant NAD Kinase (NADK)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP158Po01	Monoclonal Antibody to NAD Kinase (NADK)	WB; IHC; ICC; IP.
Antibodies	PAP158Po01	Polyclonal Antibody to NAD Kinase (NADK)	WB; IHC; ICC; IF.
Assay Kits	CLP158Po01	CLIA Kit for NAD Kinase (NADK)	CLIA assay for Antigen Detection
Assay Kits	ELP158Po01	ELISA Kit for NAD Kinase (NADK)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP158Bo01	Recombinant NAD Kinase (NADK)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP158Bo01	Monoclonal Antibody to NAD Kinase (NADK)	WB; IHC; ICC; IP.
Antibodies	PAP158Bo01	Polyclonal Antibody to NAD Kinase (NADK)	WB; IHC; ICC; IF.
Assay Kits	CLP158Bo01	CLIA Kit for NAD Kinase (NADK)	CLIA assay for Antigen Detection
Assay Kits	ELP158Bo01	ELISA Kit for NAD Kinase (NADK)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP158Rb01	Recombinant NAD Kinase (NADK)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP158Rb01	Monoclonal Antibody to NAD Kinase (NADK)	WB; IHC; ICC; IP.
Antibodies	PAP158Rb01	Polyclonal Antibody to NAD Kinase (NADK)	WB; IHC; ICC; IF.
Assay Kits	CLP158Rb01	CLIA Kit for NAD Kinase (NADK)	CLIA assay for Antigen Detection
Assay Kits	ELP158Rb01	ELISA Kit for NAD Kinase (NADK)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP158Mo01	Recombinant NAD Kinase (NADK)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP158Mo01	Monoclonal Antibody to NAD Kinase (NADK)	WB; IHC; ICC; IP.
Antibodies	PAP158Mo01	Polyclonal Antibody to NAD Kinase (NADK)	WB; IHC; ICC; IF.
Assay Kits	CLP158Mo01	CLIA Kit for NAD Kinase (NADK)	CLIA assay for Antigen Detection
Assay Kits	ELP158Mo01	ELISA Kit for NAD Kinase (NADK)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Structural and functional characterization of human NAD kinase."
Biochem. Biophys. Res. Commun. 288:69-74(2001) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of human NAD kinase."
Submitted (NOV-2010) to the PDB data bank