Mevalonate Decarboxylase (MVD)

MPD; Mevalonate Pyrophosphate Decarboxylase; Diphosphomevalonate decarboxylase; Mevalonate (diphospho)decarboxylase

SPN	P133
HGNC	7529
MGI	2179327
PubMed	22203490
RGD	621292
UniProt	P53602
Wiki	MVD

The enzyme mevalonate pyrophosphate decarboxylase (MVD, EC 4.1.1.33) catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate. This unusual enzyme decarboxylates and dehydrates its substrate while hydrolyzing ATP. As a unique enzyme in one of the early steps in cholesterol biosynthesis, MVD may be a useful target for drugs aimed at lowering serum cholesterol levels.

Toth and Huwyler (1996) cloned the human MVD gene from a liver cDNA library. The cDNA encoded a 400-amino acid polypeptide. Northern blot analysis revealed a 2-kb mRNA present at similar levels in various human tissues. Expression studies indicated that the recombinant human enzyme is active as a 43-kD homodimer.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP133Hu01	Recombinant Mevalonate Decarboxylase (MVD)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP133Hu01	Monoclonal Antibody to Mevalonate Decarboxylase (MVD)	WB; IHC; ICC; IP.
Antibodies	PAP133Hu01	Polyclonal Antibody to Mevalonate Decarboxylase (MVD)	WB; IHC; ICC; IF.
Assay Kits	CLP133Hu01	CLIA Kit for Mevalonate Decarboxylase (MVD)	CLIA assay for Antigen Detection
Assay Kits	ELP133Hu01	ELISA Kit for Mevalonate Decarboxylase (MVD)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP133Mu01	Recombinant Mevalonate Decarboxylase (MVD)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP133Mu01	Monoclonal Antibody to Mevalonate Decarboxylase (MVD)	WB; IHC; ICC; IP.
Antibodies	PAP133Mu01	Polyclonal Antibody to Mevalonate Decarboxylase (MVD)	WB; IHC; ICC; IF.
Assay Kits	CLP133Mu01	CLIA Kit for Mevalonate Decarboxylase (MVD)	CLIA assay for Antigen Detection
Assay Kits	ELP133Mu01	ELISA Kit for Mevalonate Decarboxylase (MVD)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP133Ra01	Recombinant Mevalonate Decarboxylase (MVD)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP133Ra01	Monoclonal Antibody to Mevalonate Decarboxylase (MVD)	WB; IHC; ICC; IP.
Antibodies	PAP133Ra01	Polyclonal Antibody to Mevalonate Decarboxylase (MVD)	WB; IHC; ICC; IF.
Assay Kits	CLP133Ra01	CLIA Kit for Mevalonate Decarboxylase (MVD)	CLIA assay for Antigen Detection
Assay Kits	ELP133Ra01	ELISA Kit for Mevalonate Decarboxylase (MVD)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP133Ca01	Recombinant Mevalonate Decarboxylase (MVD)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP133Ca01	Monoclonal Antibody to Mevalonate Decarboxylase (MVD)	WB; IHC; ICC; IP.
Antibodies	PAP133Ca01	Polyclonal Antibody to Mevalonate Decarboxylase (MVD)	WB; IHC; ICC; IF.
Assay Kits	CLP133Ca01	CLIA Kit for Mevalonate Decarboxylase (MVD)	CLIA assay for Antigen Detection
Assay Kits	ELP133Ca01	ELISA Kit for Mevalonate Decarboxylase (MVD)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP133Po01	Recombinant Mevalonate Decarboxylase (MVD)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP133Po01	Monoclonal Antibody to Mevalonate Decarboxylase (MVD)	WB; IHC; ICC; IP.
Antibodies	PAP133Po01	Polyclonal Antibody to Mevalonate Decarboxylase (MVD)	WB; IHC; ICC; IF.
Assay Kits	CLP133Po01	CLIA Kit for Mevalonate Decarboxylase (MVD)	CLIA assay for Antigen Detection
Assay Kits	ELP133Po01	ELISA Kit for Mevalonate Decarboxylase (MVD)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP133Bo01	Recombinant Mevalonate Decarboxylase (MVD)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP133Bo01	Monoclonal Antibody to Mevalonate Decarboxylase (MVD)	WB; IHC; ICC; IP.
Antibodies	PAP133Bo01	Polyclonal Antibody to Mevalonate Decarboxylase (MVD)	WB; IHC; ICC; IF.
Assay Kits	CLP133Bo01	CLIA Kit for Mevalonate Decarboxylase (MVD)	CLIA assay for Antigen Detection
Assay Kits	ELP133Bo01	ELISA Kit for Mevalonate Decarboxylase (MVD)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP133Rb01	Recombinant Mevalonate Decarboxylase (MVD)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP133Rb01	Monoclonal Antibody to Mevalonate Decarboxylase (MVD)	WB; IHC; ICC; IP.
Antibodies	PAP133Rb01	Polyclonal Antibody to Mevalonate Decarboxylase (MVD)	WB; IHC; ICC; IF.
Assay Kits	CLP133Rb01	CLIA Kit for Mevalonate Decarboxylase (MVD)	CLIA assay for Antigen Detection
Assay Kits	ELP133Rb01	ELISA Kit for Mevalonate Decarboxylase (MVD)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP133Mo01	Recombinant Mevalonate Decarboxylase (MVD)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP133Mo01	Monoclonal Antibody to Mevalonate Decarboxylase (MVD)	WB; IHC; ICC; IP.
Antibodies	PAP133Mo01	Polyclonal Antibody to Mevalonate Decarboxylase (MVD)	WB; IHC; ICC; IF.
Assay Kits	CLP133Mo01	CLIA Kit for Mevalonate Decarboxylase (MVD)	CLIA assay for Antigen Detection
Assay Kits	ELP133Mo01	ELISA Kit for Mevalonate Decarboxylase (MVD)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Molecular cloning and expression of the cDNAs encoding human and yeast mevalonate pyrophosphate decarboxylase."
J. Biol. Chem. 271:7895-7898(1996) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Post-translational regulation of mevalonate kinase by intermediates of the cholesterol and nonsterol isoprene biosynthetic pathways."
J. Lipid Res. 38:2216-2223(1997) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Human mevalonate diphosphate decarboxylase: characterization, investigation of the mevalonate diphosphate binding site, and crystal structure."
Arch. Biochem. Biophys. 480:58-67(2008) [PubMed] [Europe PMC] [Abstract]