Mesothelin (MSLN)

SMR; MPF; CAK1; Pre-pro-megakaryocyte-potentiating factor; Megakaryocyte-potentiating factor

SPN	P120
HGNC	7371
MGI	1888992
PubMed	22412141
RGD	69333
UniProt	Q13421
Wiki	Mesothelin

Mesothelin is a 40kDa protein present on normal mesothelial cells and overexpressed in several human tumors, including mesothelioma and ovarian and pancreatic adenocarcinoma. The protein was first identified by its reactivity with monoclonal antibody K1. Subsequent cloning studies showed that the mesothelin gene encodes a precursor protein that is processed to yield mesothelin which is attached to the cell membrane by a glycophosphatidylinositol linkage and a 31-kDa shed fragment named megakaryocyte-potentiating factor (MPF). Although it has been proposed that mesothelin may be involved in cell adhesion, its biological function is not known.Mesothelin is a tumour differentiation antigen that is normally present on the mesothelial cells lining the pleura, peritoneum and pericardium.

Reference

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J. Biol. Chem. 270:21984-21990(1995) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers."
Proc. Natl. Acad. Sci. U.S.A. 93:136-140(1996) [PubMed] [Europe PMC] [Abstract]

"Characterization of human mesothelin transcripts in ovarian and pancreatic cancer."
BMC Cancer 4:19-19(2004) [PubMed] [Europe PMC] [Abstract]

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Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]

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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

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J. Biol. Chem. 269:805-808(1994) [PubMed] [Europe PMC] [Abstract]

"Soluble member(s) of the mesothelin/megakaryocyte potentiating factor family are detectable in sera from patients with ovarian carcinoma."
Proc. Natl. Acad. Sci. U.S.A. 96:11531-11536(1999) [PubMed] [Europe PMC] [Abstract]

"Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion."
J. Biol. Chem. 279:9190-9198(2004) [PubMed] [Europe PMC] [Abstract]

"Megakaryocyte potentiation factor cleaved from mesothelin precursor is a useful tumor marker in the serum of patients with mesothelioma."
Clin. Cancer Res. 12:4225-4231(2006) [PubMed] [Europe PMC] [Abstract]

"Modification-specific proteomics of plasma membrane proteins: identification and characterization of glycosylphosphatidylinositol-anchored proteins released upon phospholipase D treatment."
J. Proteome Res. 5:935-943(2006) [PubMed] [Europe PMC] [Abstract]

"Recognition of mesothelin by the therapeutic antibody MORAb-009: structural and mechanistic insights."
J. Biol. Chem. 287:33123-33131(2012) [PubMed] [Europe PMC] [Abstract]