Call Now

Microphthalmia Associated Transcription Factor (MITF)

WS2A; MI; bHLHe32; Homolog Of Mouse Microphthalmia; Class E basic helix-loop-helix protein 32

MITF encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
The deduced MITF-C protein contains 519 amino acids and has a calculated molecular mass of 58.0 kD. Like the other MITF isoforms, MITF-C has a unique N terminus, and it does not have the 6-amino acid insertion found in MITF-M. .

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP090Hu01 Recombinant Microphthalmia Associated Transcription Factor (MITF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP090Hu01 Monoclonal Antibody to Microphthalmia Associated Transcription Factor (MITF) WB; IHC; ICC; IP.
PAP090Hu01 Polyclonal Antibody to Microphthalmia Associated Transcription Factor (MITF) WB; IHC; ICC; IF.
Assay Kits CLP090Hu01 CLIA Kit for Microphthalmia Associated Transcription Factor (MITF) CLIA assay for Antigen Detection
ELP090Hu01 ELISA Kit for Microphthalmia Associated Transcription Factor (MITF) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP090Mu01 Recombinant Microphthalmia Associated Transcription Factor (MITF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP090Mu01 Monoclonal Antibody to Microphthalmia Associated Transcription Factor (MITF) WB; IHC; ICC; IP.
PAP090Mu01 Polyclonal Antibody to Microphthalmia Associated Transcription Factor (MITF) WB; IHC; ICC; IF.
Assay Kits CLP090Mu01 CLIA Kit for Microphthalmia Associated Transcription Factor (MITF) CLIA assay for Antigen Detection
ELP090Mu01 ELISA Kit for Microphthalmia Associated Transcription Factor (MITF) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP090Ra01 Recombinant Microphthalmia Associated Transcription Factor (MITF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP090Ra01 Monoclonal Antibody to Microphthalmia Associated Transcription Factor (MITF) WB; IHC; ICC; IP.
PAP090Ra01 Polyclonal Antibody to Microphthalmia Associated Transcription Factor (MITF) WB; IHC; ICC; IF.
Assay Kits CLP090Ra01 CLIA Kit for Microphthalmia Associated Transcription Factor (MITF) CLIA assay for Antigen Detection
ELP090Ra01 ELISA Kit for Microphthalmia Associated Transcription Factor (MITF) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP090Ca01 Recombinant Microphthalmia Associated Transcription Factor (MITF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP090Ca01 Monoclonal Antibody to Microphthalmia Associated Transcription Factor (MITF) WB; IHC; ICC; IP.
PAP090Ca01 Polyclonal Antibody to Microphthalmia Associated Transcription Factor (MITF) WB; IHC; ICC; IF.
Assay Kits CLP090Ca01 CLIA Kit for Microphthalmia Associated Transcription Factor (MITF) CLIA assay for Antigen Detection
ELP090Ca01 ELISA Kit for Microphthalmia Associated Transcription Factor (MITF) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP090Po01 Recombinant Microphthalmia Associated Transcription Factor (MITF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP090Po01 Monoclonal Antibody to Microphthalmia Associated Transcription Factor (MITF) WB; IHC; ICC; IP.
PAP090Po01 Polyclonal Antibody to Microphthalmia Associated Transcription Factor (MITF) WB; IHC; ICC; IF.
Assay Kits CLP090Po01 CLIA Kit for Microphthalmia Associated Transcription Factor (MITF) CLIA assay for Antigen Detection
ELP090Po01 ELISA Kit for Microphthalmia Associated Transcription Factor (MITF) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP090Bo01 Recombinant Microphthalmia Associated Transcription Factor (MITF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP090Bo01 Monoclonal Antibody to Microphthalmia Associated Transcription Factor (MITF) WB; IHC; ICC; IP.
PAP090Bo01 Polyclonal Antibody to Microphthalmia Associated Transcription Factor (MITF) WB; IHC; ICC; IF.
Assay Kits CLP090Bo01 CLIA Kit for Microphthalmia Associated Transcription Factor (MITF) CLIA assay for Antigen Detection
ELP090Bo01 ELISA Kit for Microphthalmia Associated Transcription Factor (MITF) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP090Rb01 Recombinant Microphthalmia Associated Transcription Factor (MITF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP090Rb01 Monoclonal Antibody to Microphthalmia Associated Transcription Factor (MITF) WB; IHC; ICC; IP.
PAP090Rb01 Polyclonal Antibody to Microphthalmia Associated Transcription Factor (MITF) WB; IHC; ICC; IF.
Assay Kits CLP090Rb01 CLIA Kit for Microphthalmia Associated Transcription Factor (MITF) CLIA assay for Antigen Detection
ELP090Rb01 ELISA Kit for Microphthalmia Associated Transcription Factor (MITF) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP090Mo01 Recombinant Microphthalmia Associated Transcription Factor (MITF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP090Mo01 Monoclonal Antibody to Microphthalmia Associated Transcription Factor (MITF) WB; IHC; ICC; IP.
PAP090Mo01 Polyclonal Antibody to Microphthalmia Associated Transcription Factor (MITF) WB; IHC; ICC; IF.
Assay Kits CLP090Mo01 CLIA Kit for Microphthalmia Associated Transcription Factor (MITF) CLIA assay for Antigen Detection
ELP090Mo01 ELISA Kit for Microphthalmia Associated Transcription Factor (MITF) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Identification of a novel isoform of microphthalmia-associated transcription factor that is enriched in retinal pigment epithelium."
Biochem. Biophys. Res. Commun. 247:710-715(1998) [PubMed] [Europe PMC] [Abstract]

"Cloning of MITF, the human homolog of the mouse microphthalmia gene and assignment to chromosome 3p14.1-p12.3."
Hum. Mol. Genet. 3:553-557(1994) [PubMed] [Europe PMC] [Abstract]

"Mitf-Mdel, a novel melanocyte/melanoma-specific isoform of microphthalmia-associated transcription factor-M, as a candidate biomarker for melanoma."
BMC Med. 8:14-14(2010) [PubMed] [Europe PMC] [Abstract]

"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Structural organization of the human microphthalmia-associated transcription factor gene containing four alternative promoters."
Biochim. Biophys. Acta 1491:205-219(2000) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning of cDNA encoding a novel microphthalmia-associated transcription factor isoform with a distinct amino-terminus."
J. Biochem. 126:1043-1051(1999) [PubMed] [Europe PMC] [Abstract]

"c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi."
Genes Dev. 14:301-312(2000) [PubMed] [Europe PMC] [Abstract]

"Ser298 of MITF, a mutation site in Waardenburg syndrome type 2, is a phosphorylation site with functional significance."
Hum. Mol. Genet. 9:125-132(2000) [PubMed] [Europe PMC] [Abstract]

"The function of lysyl-tRNA synthetase and Ap4A as signaling regulators of MITF activity in FcepsilonRI-activated mast cells."
Immunity 20:145-151(2004) [PubMed] [Europe PMC] [Abstract]

"Sumoylation of MITF and its related family members TFE3 and TFEB."
J. Biol. Chem. 280:146-155(2005) [PubMed] [Europe PMC] [Abstract]

"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma."
Nature 480:94-98(2011) [PubMed] [Europe PMC] [Abstract]

"A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma."
Nature 480:99-103(2011) [PubMed] [Europe PMC] [Abstract]

"The tumor suppressor HINT1 regulates MITF and beta-catenin transcriptional activity in melanoma cells."
Cell Cycle 11:2206-2215(2012) [PubMed] [Europe PMC] [Abstract]

"The mutational spectrum in Waardenburg syndrome."
Hum. Mol. Genet. 4:2131-2137(1995) [PubMed] [Europe PMC] [Abstract]

"Tietz syndrome (hypopigmentation/deafness) caused by mutation of MITF."
J. Med. Genet. 37:446-448(2000) [PubMed] [Europe PMC] [Abstract]