Melanoma Inhibitory Activity Protein 1 (MIA1)
CD-RAP; Melanoma-derived growth regulatory protein
Growth and expansion of tumor cells including malignant melanomas are modulated by a complex network of growth factors, which regulate proliferation and cell-matrix interaction through a variety of different signal transduction pathways.
Bosserhoff et al. (1996) cloned the gene encoding MIA and described its genomic organization. The gene encodes a 131-amino acid prepropolypeptide with a 24-residue secretion signal peptide sequence. The authors identified the transcription start site of the gene and studied the expression characteristics of the gene promoter in human melanoma, epithelial, and undifferentiated cells. Bosserhoff et al. (1996) found by Northern blot analysis that the MIA gene was expressed in all melanoma cell lines tested but was not expressed in fibroblast or epithelial cell lines.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP085Hu01 | Recombinant Melanoma Inhibitory Activity Protein 1 (MIA1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP085Hu01 | Monoclonal Antibody to Melanoma Inhibitory Activity Protein 1 (MIA1) | WB; IHC; ICC; IP. |
| PAP085Hu01 | Polyclonal Antibody to Melanoma Inhibitory Activity Protein 1 (MIA1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP085Hu01 | CLIA Kit for Melanoma Inhibitory Activity Protein 1 (MIA1) | CLIA assay for Antigen Detection |
| ELP085Hu01 | ELISA Kit for Melanoma Inhibitory Activity Protein 1 (MIA1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP085Mu01 | Recombinant Melanoma Inhibitory Activity Protein 1 (MIA1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP085Mu01 | Monoclonal Antibody to Melanoma Inhibitory Activity Protein 1 (MIA1) | WB; IHC; ICC; IP. |
| PAP085Mu01 | Polyclonal Antibody to Melanoma Inhibitory Activity Protein 1 (MIA1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP085Mu01 | CLIA Kit for Melanoma Inhibitory Activity Protein 1 (MIA1) | CLIA assay for Antigen Detection |
| ELP085Mu01 | ELISA Kit for Melanoma Inhibitory Activity Protein 1 (MIA1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP085Ra01 | Recombinant Melanoma Inhibitory Activity Protein 1 (MIA1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP085Ra01 | Monoclonal Antibody to Melanoma Inhibitory Activity Protein 1 (MIA1) | WB; IHC; ICC; IP. |
| PAP085Ra01 | Polyclonal Antibody to Melanoma Inhibitory Activity Protein 1 (MIA1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP085Ra01 | CLIA Kit for Melanoma Inhibitory Activity Protein 1 (MIA1) | CLIA assay for Antigen Detection |
| ELP085Ra01 | ELISA Kit for Melanoma Inhibitory Activity Protein 1 (MIA1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP085Ca01 | Recombinant Melanoma Inhibitory Activity Protein 1 (MIA1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP085Ca01 | Monoclonal Antibody to Melanoma Inhibitory Activity Protein 1 (MIA1) | WB; IHC; ICC; IP. |
| PAP085Ca01 | Polyclonal Antibody to Melanoma Inhibitory Activity Protein 1 (MIA1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP085Ca01 | CLIA Kit for Melanoma Inhibitory Activity Protein 1 (MIA1) | CLIA assay for Antigen Detection |
| ELP085Ca01 | ELISA Kit for Melanoma Inhibitory Activity Protein 1 (MIA1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP085Po01 | Recombinant Melanoma Inhibitory Activity Protein 1 (MIA1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP085Po01 | Monoclonal Antibody to Melanoma Inhibitory Activity Protein 1 (MIA1) | WB; IHC; ICC; IP. |
| PAP085Po01 | Polyclonal Antibody to Melanoma Inhibitory Activity Protein 1 (MIA1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP085Po01 | CLIA Kit for Melanoma Inhibitory Activity Protein 1 (MIA1) | CLIA assay for Antigen Detection |
| ELP085Po01 | ELISA Kit for Melanoma Inhibitory Activity Protein 1 (MIA1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP085Bo01 | Recombinant Melanoma Inhibitory Activity Protein 1 (MIA1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP085Bo01 | Monoclonal Antibody to Melanoma Inhibitory Activity Protein 1 (MIA1) | WB; IHC; ICC; IP. |
| PAP085Bo01 | Polyclonal Antibody to Melanoma Inhibitory Activity Protein 1 (MIA1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP085Bo01 | CLIA Kit for Melanoma Inhibitory Activity Protein 1 (MIA1) | CLIA assay for Antigen Detection |
| ELP085Bo01 | ELISA Kit for Melanoma Inhibitory Activity Protein 1 (MIA1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP085Rb01 | Recombinant Melanoma Inhibitory Activity Protein 1 (MIA1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP085Rb01 | Monoclonal Antibody to Melanoma Inhibitory Activity Protein 1 (MIA1) | WB; IHC; ICC; IP. |
| PAP085Rb01 | Polyclonal Antibody to Melanoma Inhibitory Activity Protein 1 (MIA1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP085Rb01 | CLIA Kit for Melanoma Inhibitory Activity Protein 1 (MIA1) | CLIA assay for Antigen Detection |
| ELP085Rb01 | ELISA Kit for Melanoma Inhibitory Activity Protein 1 (MIA1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPP085Mo01 | Recombinant Melanoma Inhibitory Activity Protein 1 (MIA1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAP085Mo01 | Monoclonal Antibody to Melanoma Inhibitory Activity Protein 1 (MIA1) | WB; IHC; ICC; IP. |
| PAP085Mo01 | Polyclonal Antibody to Melanoma Inhibitory Activity Protein 1 (MIA1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLP085Mo01 | CLIA Kit for Melanoma Inhibitory Activity Protein 1 (MIA1) | CLIA assay for Antigen Detection |
| ELP085Mo01 | ELISA Kit for Melanoma Inhibitory Activity Protein 1 (MIA1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Cloning of a novel malignant melanoma-derived growth-regulatory protein, MIA."
Cancer Res. 54:5695-5701(1994) [PubMed] [Europe PMC] [Abstract]
"Structure and promoter analysis of the gene encoding the human melanoma-inhibiting protein MIA."
J. Biol. Chem. 271:490-495(1996) [PubMed] [Europe PMC] [Abstract]
"Cloning and characterization of the expression pattern of a novel splice product MIA (splice) of malignant melanoma-derived growth-inhibiting activity (MIA/CD-RAP)."
J. Invest. Dermatol. 119:562-569(2002) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
"Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."
BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
"Identification of IGPR-1 as a novel adhesion molecule involved in angiogenesis."
Mol. Biol. Cell 23:1646-1656(2012) [PubMed] [Europe PMC] [Abstract]
"Structure of melanoma inhibitory activity protein, a member of a recently identified family of secreted proteins."
Proc. Natl. Acad. Sci. U.S.A. 98:5515-5520(2001) [PubMed] [Europe PMC] [Abstract]