Mannosyl Alpha-1,6-Glycoprotein Beta-1,6-N-Acetylglucosaminyltransferase (MGAT5)

GNT-V; GGNT5; Mannoside acetylglucosaminyltransferase 5; N-acetylglucosaminyl-transferase V; Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A

SPN	P078
HGNC	7049
MGI	894701
PubMed	10700233
RGD	620100
UniProt	Q09328
Wiki	MGAT5

MGAT5 encodes mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, a glycosyltransferase involved in the synthesis of protein-bound and lipid-bound oligosaccharides. Alterations of the oligosaccharides on cell surface glycoproteins cause significant changes in the adhesive or migratory behavior of a cell. Increase in the encoded protein's activity may correlate with the progression of invasive malignancies.

MGAT5 expression in all tissues examined. Highest expression was in spleen, followed by pancreas, placenta, and testis, and expression was almost undetectable in skeletal muscle.MGAT5 expression in brain, heart, kidney, and placenta, with lower levels in other tissues. RNA dot blot analysis confirmed widespread MGAT5 expression.

Reference

"cDNA cloning and chromosomal mapping of human N-acetylglucosaminyltransferase V+."
Biochem. Biophys. Res. Commun. 198:318-327(1994) [PubMed] [Europe PMC] [Abstract]

"Characterization of UDP-N-acetylglucosamine: alpha-6-d-mannoside beta-1,6-N-acetylglucosaminyltransferase V from a human hepatoma cell line Hep3B."
Arch. Biochem. Biophys. 367:281-288(1999) [PubMed] [Europe PMC] [Abstract]