Malate Dehydrogenase 2 (MDH2)

M-MDH; MDH; MOR1; Malate Dehydrogenase 2,NAD(Mitochondrial)

SPN	P063
HGNC	6971
MGI	97050
PubMed	1505215
RGD	619719
UniProt	P40926
Wiki	MDH2

In both leukocytes and placentas, Davidson and Cortner (1967) found polymorphism of the malate dehydrogenase that is bound to mitochondria, called M-MDH originally and now symbolized MDH2. The fact that mitochondrial malate dehydrogenase was indistinguishable from normal in persons with variation in the supernatant MDH indicates that a separate locus is involved in its genetic determination. Mendelian segregation rather than maternal inheritance of MDH2 suggests that not all mitochondrial proteins are coded by mitochondrial DNA. Mitochondrial glutamic oxaloacetic transaminase is also determined by nuclear genes. From study of hybrid cells, Van Heyningen et al. (1975) mapped the locus for MDH2 to chromosome 7. Habets et al. (1992) subsequently mapped the locus to 7cen-q22.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP063Hu01	Recombinant Malate Dehydrogenase 2 (MDH2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP063Hu01	Monoclonal Antibody to Malate Dehydrogenase 2 (MDH2)	WB; IHC; ICC; IP.
Antibodies	PAP063Hu01	Polyclonal Antibody to Malate Dehydrogenase 2 (MDH2)	WB; IHC; ICC; IF.
Assay Kits	CLP063Hu01	CLIA Kit for Malate Dehydrogenase 2 (MDH2)	CLIA assay for Antigen Detection
Assay Kits	ELP063Hu01	ELISA Kit for Malate Dehydrogenase 2 (MDH2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP063Mu01	Recombinant Malate Dehydrogenase 2 (MDH2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP063Mu01	Monoclonal Antibody to Malate Dehydrogenase 2 (MDH2)	WB; IHC; ICC; IP.
Antibodies	PAP063Mu01	Polyclonal Antibody to Malate Dehydrogenase 2 (MDH2)	WB; IHC; ICC; IF.
Assay Kits	CLP063Mu01	CLIA Kit for Malate Dehydrogenase 2 (MDH2)	CLIA assay for Antigen Detection
Assay Kits	ELP063Mu01	ELISA Kit for Malate Dehydrogenase 2 (MDH2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP063Ra01	Recombinant Malate Dehydrogenase 2 (MDH2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP063Ra01	Monoclonal Antibody to Malate Dehydrogenase 2 (MDH2)	WB; IHC; ICC; IP.
Antibodies	PAP063Ra01	Polyclonal Antibody to Malate Dehydrogenase 2 (MDH2)	WB; IHC; ICC; IF.
Assay Kits	CLP063Ra01	CLIA Kit for Malate Dehydrogenase 2 (MDH2)	CLIA assay for Antigen Detection
Assay Kits	ELP063Ra01	ELISA Kit for Malate Dehydrogenase 2 (MDH2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP063Ca01	Recombinant Malate Dehydrogenase 2 (MDH2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP063Ca01	Monoclonal Antibody to Malate Dehydrogenase 2 (MDH2)	WB; IHC; ICC; IP.
Antibodies	PAP063Ca01	Polyclonal Antibody to Malate Dehydrogenase 2 (MDH2)	WB; IHC; ICC; IF.
Assay Kits	CLP063Ca01	CLIA Kit for Malate Dehydrogenase 2 (MDH2)	CLIA assay for Antigen Detection
Assay Kits	ELP063Ca01	ELISA Kit for Malate Dehydrogenase 2 (MDH2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP063Po01	Recombinant Malate Dehydrogenase 2 (MDH2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP063Po01	Monoclonal Antibody to Malate Dehydrogenase 2 (MDH2)	WB; IHC; ICC; IP.
Antibodies	PAP063Po01	Polyclonal Antibody to Malate Dehydrogenase 2 (MDH2)	WB; IHC; ICC; IF.
Assay Kits	CLP063Po01	CLIA Kit for Malate Dehydrogenase 2 (MDH2)	CLIA assay for Antigen Detection
Assay Kits	ELP063Po01	ELISA Kit for Malate Dehydrogenase 2 (MDH2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP063Bo01	Recombinant Malate Dehydrogenase 2 (MDH2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP063Bo01	Monoclonal Antibody to Malate Dehydrogenase 2 (MDH2)	WB; IHC; ICC; IP.
Antibodies	PAP063Bo01	Polyclonal Antibody to Malate Dehydrogenase 2 (MDH2)	WB; IHC; ICC; IF.
Assay Kits	CLP063Bo01	CLIA Kit for Malate Dehydrogenase 2 (MDH2)	CLIA assay for Antigen Detection
Assay Kits	ELP063Bo01	ELISA Kit for Malate Dehydrogenase 2 (MDH2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP063Rb01	Recombinant Malate Dehydrogenase 2 (MDH2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP063Rb01	Monoclonal Antibody to Malate Dehydrogenase 2 (MDH2)	WB; IHC; ICC; IP.
Antibodies	PAP063Rb01	Polyclonal Antibody to Malate Dehydrogenase 2 (MDH2)	WB; IHC; ICC; IF.
Assay Kits	CLP063Rb01	CLIA Kit for Malate Dehydrogenase 2 (MDH2)	CLIA assay for Antigen Detection
Assay Kits	ELP063Rb01	ELISA Kit for Malate Dehydrogenase 2 (MDH2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPP063Mo01	Recombinant Malate Dehydrogenase 2 (MDH2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAP063Mo01	Monoclonal Antibody to Malate Dehydrogenase 2 (MDH2)	WB; IHC; ICC; IP.
Antibodies	PAP063Mo01	Polyclonal Antibody to Malate Dehydrogenase 2 (MDH2)	WB; IHC; ICC; IF.
Assay Kits	CLP063Mo01	CLIA Kit for Malate Dehydrogenase 2 (MDH2)	CLIA assay for Antigen Detection
Assay Kits	ELP063Mo01	ELISA Kit for Malate Dehydrogenase 2 (MDH2)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of human chromosome 7."
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"Regulation of cellular metabolism by protein lysine acetylation."
Science 327:1000-1004(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"The first identification of lysine malonylation substrates and its regulatory enzyme."
Mol. Cell. Proteomics 10:M111.012658.01-M111.012658.12(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of human malate dehydrogenase type 2."
Submitted (MAR-2006) to the PDB data bank