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MYC Associated Factor X (MAX)

BHLHD4; Class D basic helix-loop-helix protein 4

MAX is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Unlike MYC, the steady state level of MAX RNA was not significantly modulated with respect to proliferation or differentiation. Unlike MYC RNA, MAX RNA was relatively stable with a half-life of more than 3 hours, and therefore it did not exhibit the characteristic short half-life of RNAs encoded by most immediate early genes.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP059Hu01 Recombinant MYC Associated Factor X (MAX) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP059Hu01 Monoclonal Antibody to MYC Associated Factor X (MAX) WB; IHC; ICC; IP.
PAP059Hu01 Polyclonal Antibody to MYC Associated Factor X (MAX) WB; IHC; ICC; IF.
Assay Kits CLP059Hu01 CLIA Kit for MYC Associated Factor X (MAX) CLIA assay for Antigen Detection
ELP059Hu01 ELISA Kit for MYC Associated Factor X (MAX) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP059Mu01 Recombinant MYC Associated Factor X (MAX) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP059Mu01 Monoclonal Antibody to MYC Associated Factor X (MAX) WB; IHC; ICC; IP.
PAP059Mu01 Polyclonal Antibody to MYC Associated Factor X (MAX) WB; IHC; ICC; IF.
Assay Kits CLP059Mu01 CLIA Kit for MYC Associated Factor X (MAX) CLIA assay for Antigen Detection
ELP059Mu01 ELISA Kit for MYC Associated Factor X (MAX) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP059Ra01 Recombinant MYC Associated Factor X (MAX) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP059Ra01 Monoclonal Antibody to MYC Associated Factor X (MAX) WB; IHC; ICC; IP.
PAP059Ra01 Polyclonal Antibody to MYC Associated Factor X (MAX) WB; IHC; ICC; IF.
Assay Kits CLP059Ra01 CLIA Kit for MYC Associated Factor X (MAX) CLIA assay for Antigen Detection
ELP059Ra01 ELISA Kit for MYC Associated Factor X (MAX) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP059Ca01 Recombinant MYC Associated Factor X (MAX) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP059Ca01 Monoclonal Antibody to MYC Associated Factor X (MAX) WB; IHC; ICC; IP.
PAP059Ca01 Polyclonal Antibody to MYC Associated Factor X (MAX) WB; IHC; ICC; IF.
Assay Kits CLP059Ca01 CLIA Kit for MYC Associated Factor X (MAX) CLIA assay for Antigen Detection
ELP059Ca01 ELISA Kit for MYC Associated Factor X (MAX) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP059Po01 Recombinant MYC Associated Factor X (MAX) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP059Po01 Monoclonal Antibody to MYC Associated Factor X (MAX) WB; IHC; ICC; IP.
PAP059Po01 Polyclonal Antibody to MYC Associated Factor X (MAX) WB; IHC; ICC; IF.
Assay Kits CLP059Po01 CLIA Kit for MYC Associated Factor X (MAX) CLIA assay for Antigen Detection
ELP059Po01 ELISA Kit for MYC Associated Factor X (MAX) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP059Bo01 Recombinant MYC Associated Factor X (MAX) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP059Bo01 Monoclonal Antibody to MYC Associated Factor X (MAX) WB; IHC; ICC; IP.
PAP059Bo01 Polyclonal Antibody to MYC Associated Factor X (MAX) WB; IHC; ICC; IF.
Assay Kits CLP059Bo01 CLIA Kit for MYC Associated Factor X (MAX) CLIA assay for Antigen Detection
ELP059Bo01 ELISA Kit for MYC Associated Factor X (MAX) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP059Rb01 Recombinant MYC Associated Factor X (MAX) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP059Rb01 Monoclonal Antibody to MYC Associated Factor X (MAX) WB; IHC; ICC; IP.
PAP059Rb01 Polyclonal Antibody to MYC Associated Factor X (MAX) WB; IHC; ICC; IF.
Assay Kits CLP059Rb01 CLIA Kit for MYC Associated Factor X (MAX) CLIA assay for Antigen Detection
ELP059Rb01 ELISA Kit for MYC Associated Factor X (MAX) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP059Mo01 Recombinant MYC Associated Factor X (MAX) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP059Mo01 Monoclonal Antibody to MYC Associated Factor X (MAX) WB; IHC; ICC; IP.
PAP059Mo01 Polyclonal Antibody to MYC Associated Factor X (MAX) WB; IHC; ICC; IF.
Assay Kits CLP059Mo01 CLIA Kit for MYC Associated Factor X (MAX) CLIA assay for Antigen Detection
ELP059Mo01 ELISA Kit for MYC Associated Factor X (MAX) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc."
Science 251:1211-1217(1991) [PubMed] [Europe PMC] [Abstract]

"Alternative mRNA forms and open reading frames of the max gene."
Oncogene 8:503-507(1993) [PubMed] [Europe PMC] [Abstract]

"Alternative forms of Max as enhancers or suppressors of Myc-ras cotransformation."
Science 256:373-377(1992) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 14."
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells."
Science 296:1132-1136(2002) [PubMed] [Europe PMC] [Abstract]

"An unappreciated role for RNA surveillance."
Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]

"Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF."
Cell 121:873-885(2005) [PubMed] [Europe PMC] [Abstract]

"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

"Max is acetylated by p300 at several nuclear localization residues."
Biochem. J. 403:397-407(2007) [PubMed] [Europe PMC] [Abstract]

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"Recognition by Max of its cognate DNA through a dimeric b/HLH/Z domain."
Nature 363:38-45(1993) [PubMed] [Europe PMC] [Abstract]

"The crystal structure of an intact human Max-DNA complex: new insights into mechanisms of transcriptional control."
Structure 5:509-520(1997) [PubMed] [Europe PMC] [Abstract]