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Leucyl/Cystinyl Aminopeptidase (LNPEP)

CAP; PLAP; OTASE; IRAP; Oxytocinase; Insulin-regulated membrane aminopeptidase; Insulin-responsive aminopeptidase; Placental leucine aminopeptidase

LNPEP encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms.
The deduced 944-amino acid polypeptide contains the HEXXH consensus sequence of zinc metallopeptidases as well as an N-terminal hydrophobic region that resembles a transmembrane domain.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP013Hu01 Recombinant Leucyl/Cystinyl Aminopeptidase (LNPEP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP013Hu01 Monoclonal Antibody to Leucyl/Cystinyl Aminopeptidase (LNPEP) WB; IHC; ICC; IP.
PAP013Hu01 Polyclonal Antibody to Leucyl/Cystinyl Aminopeptidase (LNPEP) WB; IHC; ICC; IF.
Assay Kits CLP013Hu01 CLIA Kit for Leucyl/Cystinyl Aminopeptidase (LNPEP) CLIA assay for Antigen Detection
ELP013Hu01 ELISA Kit for Leucyl/Cystinyl Aminopeptidase (LNPEP) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP013Mu01 Recombinant Leucyl/Cystinyl Aminopeptidase (LNPEP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP013Mu01 Monoclonal Antibody to Leucyl/Cystinyl Aminopeptidase (LNPEP) WB; IHC; ICC; IP.
PAP013Mu01 Polyclonal Antibody to Leucyl/Cystinyl Aminopeptidase (LNPEP) WB; IHC; ICC; IF.
Assay Kits CLP013Mu01 CLIA Kit for Leucyl/Cystinyl Aminopeptidase (LNPEP) CLIA assay for Antigen Detection
ELP013Mu01 ELISA Kit for Leucyl/Cystinyl Aminopeptidase (LNPEP) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP013Ra01 Recombinant Leucyl/Cystinyl Aminopeptidase (LNPEP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP013Ra01 Monoclonal Antibody to Leucyl/Cystinyl Aminopeptidase (LNPEP) WB; IHC; ICC; IP.
PAP013Ra01 Polyclonal Antibody to Leucyl/Cystinyl Aminopeptidase (LNPEP) WB; IHC; ICC; IF.
Assay Kits CLP013Ra01 CLIA Kit for Leucyl/Cystinyl Aminopeptidase (LNPEP) CLIA assay for Antigen Detection
ELP013Ra01 ELISA Kit for Leucyl/Cystinyl Aminopeptidase (LNPEP) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP013Ca01 Recombinant Leucyl/Cystinyl Aminopeptidase (LNPEP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP013Ca01 Monoclonal Antibody to Leucyl/Cystinyl Aminopeptidase (LNPEP) WB; IHC; ICC; IP.
PAP013Ca01 Polyclonal Antibody to Leucyl/Cystinyl Aminopeptidase (LNPEP) WB; IHC; ICC; IF.
Assay Kits CLP013Ca01 CLIA Kit for Leucyl/Cystinyl Aminopeptidase (LNPEP) CLIA assay for Antigen Detection
ELP013Ca01 ELISA Kit for Leucyl/Cystinyl Aminopeptidase (LNPEP) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP013Po01 Recombinant Leucyl/Cystinyl Aminopeptidase (LNPEP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP013Po01 Monoclonal Antibody to Leucyl/Cystinyl Aminopeptidase (LNPEP) WB; IHC; ICC; IP.
PAP013Po01 Polyclonal Antibody to Leucyl/Cystinyl Aminopeptidase (LNPEP) WB; IHC; ICC; IF.
Assay Kits CLP013Po01 CLIA Kit for Leucyl/Cystinyl Aminopeptidase (LNPEP) CLIA assay for Antigen Detection
ELP013Po01 ELISA Kit for Leucyl/Cystinyl Aminopeptidase (LNPEP) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP013Bo01 Recombinant Leucyl/Cystinyl Aminopeptidase (LNPEP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP013Bo01 Monoclonal Antibody to Leucyl/Cystinyl Aminopeptidase (LNPEP) WB; IHC; ICC; IP.
PAP013Bo01 Polyclonal Antibody to Leucyl/Cystinyl Aminopeptidase (LNPEP) WB; IHC; ICC; IF.
Assay Kits CLP013Bo01 CLIA Kit for Leucyl/Cystinyl Aminopeptidase (LNPEP) CLIA assay for Antigen Detection
ELP013Bo01 ELISA Kit for Leucyl/Cystinyl Aminopeptidase (LNPEP) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP013Rb01 Recombinant Leucyl/Cystinyl Aminopeptidase (LNPEP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP013Rb01 Monoclonal Antibody to Leucyl/Cystinyl Aminopeptidase (LNPEP) WB; IHC; ICC; IP.
PAP013Rb01 Polyclonal Antibody to Leucyl/Cystinyl Aminopeptidase (LNPEP) WB; IHC; ICC; IF.
Assay Kits CLP013Rb01 CLIA Kit for Leucyl/Cystinyl Aminopeptidase (LNPEP) CLIA assay for Antigen Detection
ELP013Rb01 ELISA Kit for Leucyl/Cystinyl Aminopeptidase (LNPEP) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPP013Mo01 Recombinant Leucyl/Cystinyl Aminopeptidase (LNPEP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAP013Mo01 Monoclonal Antibody to Leucyl/Cystinyl Aminopeptidase (LNPEP) WB; IHC; ICC; IP.
PAP013Mo01 Polyclonal Antibody to Leucyl/Cystinyl Aminopeptidase (LNPEP) WB; IHC; ICC; IF.
Assay Kits CLP013Mo01 CLIA Kit for Leucyl/Cystinyl Aminopeptidase (LNPEP) CLIA assay for Antigen Detection
ELP013Mo01 ELISA Kit for Leucyl/Cystinyl Aminopeptidase (LNPEP) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Human placental leucine aminopeptidase/oxytocinase. A new member of type II membrane-spanning zinc metallopeptidase family."
J. Biol. Chem. 271:56-61(1996) [PubMed] [Europe PMC] [Abstract]

"The complete amino acid sequence of human placental oxytocinase."
Biochim. Biophys. Acta 1352:1-7(1997) [PubMed] [Europe PMC] [Abstract]

"Structure of the human oxytocinase/insulin-regulated aminopeptidase gene and localization to chromosome 5q21."
Eur. J. Biochem. 267:2297-2306(2000) [PubMed] [Europe PMC] [Abstract]

"Expression of placental leucine aminopeptidase/oxytocinase in neuronal cells and its action on neuronal peptides."
Eur. J. Biochem. 268:3259-3266(2001) [PubMed] [Europe PMC] [Abstract]

"Pool sequencing of natural HLA-DR, DQ, and DP ligands reveals detailed peptide motifs, constraints of processing, and general rules."
Immunogenetics 39:230-242(1994) [PubMed] [Europe PMC] [Abstract]

"Identification of human placental leucine aminopeptidase as oxytocinase."
Arch. Biochem. Biophys. 292:388-392(1992) [PubMed] [Europe PMC] [Abstract]

"Evidence that the angiotensin IV (AT(4)) receptor is the enzyme insulin-regulated aminopeptidase."
J. Biol. Chem. 276:48623-48626(2001) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]