Lectin, Mannose Binding 2 (LMAN2)

GP36B; VIP36; C5orf8; Vesicular integral-membrane protein VIP36; Glycoprotein GP36b; Vesicular integral-membrane protein 36

SPN	P006
HGNC	16986
MGI	1914140
PubMed	23161554
UniProt	Q12907
Wiki	LMAN2

By searching an EST database for sequences similar to dog Vip36, Neve et al. (2003) identified LMAN2, which they called VIP36. The deduced 356-amino acid protein contains an N-terminal signal sequence, followed by a lectin-type carbohydrate recognition domain and a C-terminal transmembrane domain. A KRFY endoplasmic reticulum trafficking motif is located at the C terminus. Northern blot analysis detected variable expression of 1.2- and 1.4-kb VIP36 transcripts in all tissues examined. Highest expression was in kidney, placenta, and liver.

Nufer et al. (2003) determined that the LMAN2 gene contains 8 exons and spans 14.9 kb.By genomic sequence analysis, Nufer et al. (2003) mapped the LMAN2 gene to chromosome 5q35.5.

Reference

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"VIP36 localisation to the early secretory pathway."
J. Cell Sci. 112:2813-2821(1999) [PubMed] [Europe PMC] [Abstract]

"Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]