Insulin Promoter Factor 1 (IPF)

IDX1; STF1; MODY4; PDX1; GSF; IUF1; Pancreatic And Duodenal Homeobox 1; Somatostatin Transcription Factor 1; Glucose-sensitive factor; Insulin upstream factor 1

SPN	O952
HGNC	6107
MGI	102851
PubMed	10545531
RGD	62387
UniProt	P52945
Wiki	IPF

IPF is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4). IPF1 appears to be not only a key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut.

Reference

"Localization of human homeodomain transcription factor insulin promoter factor 1 (IPF1) to chromosome band 13q12.1."
Genomics 28:125-126(1995) [PubMed] [Europe PMC] [Abstract]

"Isolation, characterization, and chromosomal mapping of the human insulin promoter factor 1 (IPF-1) gene."
Diabetes 45:789-794(1996) [PubMed] [Europe PMC] [Abstract]

"The p38/reactivating kinase mitogen-activated protein kinase cascade mediates the activation of the transcription factor insulin upstream factor 1 and insulin gene transcription by high glucose in pancreatic beta-cells."
J. Biol. Chem. 272:20936-20944(1997) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 13."
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]

"Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence."
Nat. Genet. 15:106-110(1997) [PubMed] [Europe PMC] [Abstract]

"Pdx-1 links histone H3-Lys-4 methylation to RNA polymerase II elongation during activation of insulin transcription."
J. Biol. Chem. 280:36244-36253(2005) [PubMed] [Europe PMC] [Abstract]

"Pancreatic and duodenal homeobox 1 (PDX1) phosphorylation at serine-269 is HIPK2-dependent and affects PDX1 subnuclear localization."
Biochem. Biophys. Res. Commun. 399:155-161(2010) [PubMed] [Europe PMC] [Abstract]

"Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes."
J. Clin. Invest. 104:R33-R39(1999) [PubMed] [Europe PMC] [Abstract]

"Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus."
J. Clin. Invest. 104:R41-R48(1999) [PubMed] [Europe PMC] [Abstract]