Interleukin 1 Receptor Accessory Protein (IL1RAP)

IL-1RAcP; C3orf13; IL1R3; Interleukin-1 receptor 3

SPN	O925
HGNC	5995
MGI	104975
PubMed	9479509
RGD	2893
UniProt	Q9NPH3
Wiki	IL1RAP

Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes the interleukin 1 receptor accessory protein.

The protein is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. Detected in liver, skin, placenta, thymus and lung.

Reference

"Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein."
Proc. Natl. Acad. Sci. U.S.A. 94:12829-12832(1997) [PubMed] [Europe PMC] [Abstract]

"IL-1 signaling cascade in liver cells and the involvement of a soluble form of the IL-1 receptor accessory protein."
J. Immunol. 164:5277-5286(2000) [PubMed] [Europe PMC] [Abstract]

"Expression of alternatively spliced interleukin-1 receptor accessory protein mRNAs is differentially regulated during inflammation and apoptosis."
Cell. Signal. 15:793-802(2003) [PubMed] [Europe PMC] [Abstract]

"A novel alternatively spliced interleukin-1 receptor accessory protein mIL-1RAcP687."
Mol. Immunol. 45:1374-1384(2008) [PubMed] [Europe PMC] [Abstract]

"A central nervous system-restricted isoform of the interleukin-1 receptor accessory protein modulates neuronal responses to interleukin-1."
Immunity 30:817-831(2009) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The human gene encoding the interleukin-1 receptor accessory protein (IL1RAP) maps to chromosome 3q28 by fluorescence in situ hybridization and radiation hybrid mapping."
Genomics 47:325-326(1998) [PubMed] [Europe PMC] [Abstract]

"The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness."
J. Immunol. 161:6871-6877(1998) [PubMed] [Europe PMC] [Abstract]

"Characterization of a cascade of protein interactions initiated at the IL-1 receptor."
Biochem. Biophys. Res. Commun. 303:525-531(2003) [PubMed] [Europe PMC] [Abstract]

"The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action."
Immunity 18:87-96(2003) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Large-scale proteomics analysis of the human kinome."
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Structural insights into the assembly and activation of IL-1beta with its receptors."
Nat. Immunol. 11:905-911(2010) [PubMed] [Europe PMC] [Abstract]