Interleukin 18 Binding Protein (IL18BP)
IL18BPa; MC51L-53L-54L Homolog Gene Product; Tadekinig-alfa
IL18BP is an inhibitor of the proinflammatory cytokine IL18. This protein binds to IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production. This protein is constitutively expressed and secreted in mononuclear cells. The expression of this protein can be enhanced by IFN-gamma. An elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Three transcript variants encoding the same protein have been found for this gene.Sequence analysis revealed that IL18BP encodes a 192-amino acid soluble protein with a 28-amino acid signal sequence. By analysis of a genomic clone, the authors identified 3 splice variants, which they termed IL18BPa, IL18BPb, and IL18BPc.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO923Hu01 | Recombinant Interleukin 18 Binding Protein (IL18BP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO923Hu01 | Monoclonal Antibody to Interleukin 18 Binding Protein (IL18BP) | WB; IHC; ICC; IP. |
| PAO923Hu01 | Polyclonal Antibody to Interleukin 18 Binding Protein (IL18BP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO923Hu01 | CLIA Kit for Interleukin 18 Binding Protein (IL18BP) | CLIA assay for Antigen Detection |
| ELO923Hu01 | ELISA Kit for Interleukin 18 Binding Protein (IL18BP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO923Mu01 | Recombinant Interleukin 18 Binding Protein (IL18BP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO923Mu01 | Monoclonal Antibody to Interleukin 18 Binding Protein (IL18BP) | WB; IHC; ICC; IP. |
| PAO923Mu01 | Polyclonal Antibody to Interleukin 18 Binding Protein (IL18BP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO923Mu01 | CLIA Kit for Interleukin 18 Binding Protein (IL18BP) | CLIA assay for Antigen Detection |
| ELO923Mu01 | ELISA Kit for Interleukin 18 Binding Protein (IL18BP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO923Ra01 | Recombinant Interleukin 18 Binding Protein (IL18BP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO923Ra01 | Monoclonal Antibody to Interleukin 18 Binding Protein (IL18BP) | WB; IHC; ICC; IP. |
| PAO923Ra01 | Polyclonal Antibody to Interleukin 18 Binding Protein (IL18BP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO923Ra01 | CLIA Kit for Interleukin 18 Binding Protein (IL18BP) | CLIA assay for Antigen Detection |
| ELO923Ra01 | ELISA Kit for Interleukin 18 Binding Protein (IL18BP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO923Ca01 | Recombinant Interleukin 18 Binding Protein (IL18BP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO923Ca01 | Monoclonal Antibody to Interleukin 18 Binding Protein (IL18BP) | WB; IHC; ICC; IP. |
| PAO923Ca01 | Polyclonal Antibody to Interleukin 18 Binding Protein (IL18BP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO923Ca01 | CLIA Kit for Interleukin 18 Binding Protein (IL18BP) | CLIA assay for Antigen Detection |
| ELO923Ca01 | ELISA Kit for Interleukin 18 Binding Protein (IL18BP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO923Po01 | Recombinant Interleukin 18 Binding Protein (IL18BP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO923Po01 | Monoclonal Antibody to Interleukin 18 Binding Protein (IL18BP) | WB; IHC; ICC; IP. |
| PAO923Po01 | Polyclonal Antibody to Interleukin 18 Binding Protein (IL18BP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO923Po01 | CLIA Kit for Interleukin 18 Binding Protein (IL18BP) | CLIA assay for Antigen Detection |
| ELO923Po01 | ELISA Kit for Interleukin 18 Binding Protein (IL18BP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO923Bo01 | Recombinant Interleukin 18 Binding Protein (IL18BP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO923Bo01 | Monoclonal Antibody to Interleukin 18 Binding Protein (IL18BP) | WB; IHC; ICC; IP. |
| PAO923Bo01 | Polyclonal Antibody to Interleukin 18 Binding Protein (IL18BP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO923Bo01 | CLIA Kit for Interleukin 18 Binding Protein (IL18BP) | CLIA assay for Antigen Detection |
| ELO923Bo01 | ELISA Kit for Interleukin 18 Binding Protein (IL18BP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO923Rb01 | Recombinant Interleukin 18 Binding Protein (IL18BP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO923Rb01 | Monoclonal Antibody to Interleukin 18 Binding Protein (IL18BP) | WB; IHC; ICC; IP. |
| PAO923Rb01 | Polyclonal Antibody to Interleukin 18 Binding Protein (IL18BP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO923Rb01 | CLIA Kit for Interleukin 18 Binding Protein (IL18BP) | CLIA assay for Antigen Detection |
| ELO923Rb01 | ELISA Kit for Interleukin 18 Binding Protein (IL18BP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO923Mo01 | Recombinant Interleukin 18 Binding Protein (IL18BP) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO923Mo01 | Monoclonal Antibody to Interleukin 18 Binding Protein (IL18BP) | WB; IHC; ICC; IP. |
| PAO923Mo01 | Polyclonal Antibody to Interleukin 18 Binding Protein (IL18BP) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO923Mo01 | CLIA Kit for Interleukin 18 Binding Protein (IL18BP) | CLIA assay for Antigen Detection |
| ELO923Mo01 | ELISA Kit for Interleukin 18 Binding Protein (IL18BP) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response."
Immunity 10:127-136(1999) [PubMed] [Europe PMC] [Abstract]
"Cloning and expression of interleukin-18 binding protein."
FEBS Lett. 445:338-342(1999) [PubMed] [Europe PMC] [Abstract]
"Identification of human and mouse homologs of the MC51L-53L-54L family of secreted glycoproteins encoded by the Molluscum contagiosum poxvirus."
Virology 257:297-302(1999) [PubMed] [Europe PMC] [Abstract]
"Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18."
Proc. Natl. Acad. Sci. U.S.A. 97:1190-1195(2000) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
"Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."
Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]