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Hornerin (HRNR)

S100a18

Hornerin was expressed in the upper epidermis of newborn mouse skin, as was profilaggrin. In addition, both hornerin and profilaggrin were expressed in the tongue, esophagus, and forestomach. In all four tissues, immunostaining for hornerin and profilaggrin showed a granular pattern, and most of the signals for the two proteins were co-localized on keratohyalin granules. This was confirmed by double immunoelectron microscopy. Within keratohyalin granules, hornerin was detected more frequently in the periphery, whereas profilaggrin was equally distributed. A quantitative RT-PCR revealed that both genes were expressed at highest levels in the forestomach and at the next highest levels in skin. Profilaggrin mRNA was most abundant in the forestomach. In skin, the amount of hornerin mRNA was more than fourfold greater than the amount of profilaggrin mRNA.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPO864Hu01 Recombinant Hornerin (HRNR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAO864Hu01 Monoclonal Antibody to Hornerin (HRNR) WB; IHC; ICC; IP.
PAO864Hu01 Polyclonal Antibody to Hornerin (HRNR) WB; IHC; ICC; IF.
Assay Kits CLO864Hu01 CLIA Kit for Hornerin (HRNR) CLIA assay for Antigen Detection
ELO864Hu01 ELISA Kit for Hornerin (HRNR) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPO864Mu01 Recombinant Hornerin (HRNR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAO864Mu01 Monoclonal Antibody to Hornerin (HRNR) WB; IHC; ICC; IP.
PAO864Mu01 Polyclonal Antibody to Hornerin (HRNR) WB; IHC; ICC; IF.
Assay Kits CLO864Mu01 CLIA Kit for Hornerin (HRNR) CLIA assay for Antigen Detection
ELO864Mu01 ELISA Kit for Hornerin (HRNR) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPO864Ra01 Recombinant Hornerin (HRNR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAO864Ra01 Monoclonal Antibody to Hornerin (HRNR) WB; IHC; ICC; IP.
PAO864Ra01 Polyclonal Antibody to Hornerin (HRNR) WB; IHC; ICC; IF.
Assay Kits CLO864Ra01 CLIA Kit for Hornerin (HRNR) CLIA assay for Antigen Detection
ELO864Ra01 ELISA Kit for Hornerin (HRNR) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPO864Ca01 Recombinant Hornerin (HRNR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAO864Ca01 Monoclonal Antibody to Hornerin (HRNR) WB; IHC; ICC; IP.
PAO864Ca01 Polyclonal Antibody to Hornerin (HRNR) WB; IHC; ICC; IF.
Assay Kits CLO864Ca01 CLIA Kit for Hornerin (HRNR) CLIA assay for Antigen Detection
ELO864Ca01 ELISA Kit for Hornerin (HRNR) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPO864Po01 Recombinant Hornerin (HRNR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAO864Po01 Monoclonal Antibody to Hornerin (HRNR) WB; IHC; ICC; IP.
PAO864Po01 Polyclonal Antibody to Hornerin (HRNR) WB; IHC; ICC; IF.
Assay Kits CLO864Po01 CLIA Kit for Hornerin (HRNR) CLIA assay for Antigen Detection
ELO864Po01 ELISA Kit for Hornerin (HRNR) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPO864Bo01 Recombinant Hornerin (HRNR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAO864Bo01 Monoclonal Antibody to Hornerin (HRNR) WB; IHC; ICC; IP.
PAO864Bo01 Polyclonal Antibody to Hornerin (HRNR) WB; IHC; ICC; IF.
Assay Kits CLO864Bo01 CLIA Kit for Hornerin (HRNR) CLIA assay for Antigen Detection
ELO864Bo01 ELISA Kit for Hornerin (HRNR) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPO864Rb01 Recombinant Hornerin (HRNR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAO864Rb01 Monoclonal Antibody to Hornerin (HRNR) WB; IHC; ICC; IP.
PAO864Rb01 Polyclonal Antibody to Hornerin (HRNR) WB; IHC; ICC; IF.
Assay Kits CLO864Rb01 CLIA Kit for Hornerin (HRNR) CLIA assay for Antigen Detection
ELO864Rb01 ELISA Kit for Hornerin (HRNR) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPO864Mo01 Recombinant Hornerin (HRNR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAO864Mo01 Monoclonal Antibody to Hornerin (HRNR) WB; IHC; ICC; IP.
PAO864Mo01 Polyclonal Antibody to Hornerin (HRNR) WB; IHC; ICC; IF.
Assay Kits CLO864Mo01 CLIA Kit for Hornerin (HRNR) CLIA assay for Antigen Detection
ELO864Mo01 ELISA Kit for Hornerin (HRNR) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Identification of human hornerin and its expression in regenerating and psoriatic skin."
J. Biol. Chem. 280:4696-4703(2005) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"Large-scale proteomics analysis of the human kinome."
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Hornerin is a component of the epidermal cornified cell envelopes."
FASEB J. 25:1567-1576(2011) [PubMed] [Europe PMC] [Abstract]

"Ultraviolet B irradiation induces the expression of hornerin in xenotransplanted human skin."
Acta Histochem. 116:20-24(2014) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]