Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4)
HCN4 encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15. The HCN4 cDNA predicts a protein of 1,203 amino acids. HCN4 contains 6 putative transmembrane segments, a pore region, and a cyclic nucleotide-binding domain (CNBD). Northern blot and PCR analyses showed that HCN4 is expressed at heart ventricle and atrium.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO823Hu01 | Recombinant Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO823Hu01 | Monoclonal Antibody to Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4) | WB; IHC; ICC; IP. |
| PAO823Hu01 | Polyclonal Antibody to Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO823Hu01 | CLIA Kit for Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4) | CLIA assay for Antigen Detection |
| ELO823Hu01 | ELISA Kit for Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO823Mu01 | Recombinant Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO823Mu01 | Monoclonal Antibody to Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4) | WB; IHC; ICC; IP. |
| PAO823Mu01 | Polyclonal Antibody to Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO823Mu01 | CLIA Kit for Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4) | CLIA assay for Antigen Detection |
| ELO823Mu01 | ELISA Kit for Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO823Ra01 | Recombinant Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO823Ra01 | Monoclonal Antibody to Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4) | WB; IHC; ICC; IP. |
| PAO823Ra01 | Polyclonal Antibody to Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO823Ra01 | CLIA Kit for Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4) | CLIA assay for Antigen Detection |
| ELO823Ra01 | ELISA Kit for Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO823Ca01 | Recombinant Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO823Ca01 | Monoclonal Antibody to Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4) | WB; IHC; ICC; IP. |
| PAO823Ca01 | Polyclonal Antibody to Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO823Ca01 | CLIA Kit for Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4) | CLIA assay for Antigen Detection |
| ELO823Ca01 | ELISA Kit for Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO823Po01 | Recombinant Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO823Po01 | Monoclonal Antibody to Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4) | WB; IHC; ICC; IP. |
| PAO823Po01 | Polyclonal Antibody to Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO823Po01 | CLIA Kit for Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4) | CLIA assay for Antigen Detection |
| ELO823Po01 | ELISA Kit for Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO823Bo01 | Recombinant Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO823Bo01 | Monoclonal Antibody to Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4) | WB; IHC; ICC; IP. |
| PAO823Bo01 | Polyclonal Antibody to Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO823Bo01 | CLIA Kit for Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4) | CLIA assay for Antigen Detection |
| ELO823Bo01 | ELISA Kit for Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO823Rb01 | Recombinant Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO823Rb01 | Monoclonal Antibody to Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4) | WB; IHC; ICC; IP. |
| PAO823Rb01 | Polyclonal Antibody to Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO823Rb01 | CLIA Kit for Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4) | CLIA assay for Antigen Detection |
| ELO823Rb01 | ELISA Kit for Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO823Mo01 | Recombinant Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO823Mo01 | Monoclonal Antibody to Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4) | WB; IHC; ICC; IP. |
| PAO823Mo01 | Polyclonal Antibody to Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO823Mo01 | CLIA Kit for Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4) | CLIA assay for Antigen Detection |
| ELO823Mo01 | ELISA Kit for Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Two pacemaker channels from human heart with profoundly different activation kinetics."
EMBO J. 18:2323-2329(1999) [PubMed] [Europe PMC] [Abstract]
"Molecular characterization of a slowly gating human hyperpolarization-activated channel predominantly expressed in thalamus, heart, and testis."
Proc. Natl. Acad. Sci. U.S.A. 96:9391-9396(1999) [PubMed] [Europe PMC] [Abstract]
"Role of HCN4 channel in preventing ventricular arrhythmia."
J. Hum. Genet. 54:115-121(2009) [PubMed] [Europe PMC] [Abstract]
"Structural basis for the cAMP-dependent gating in the human HCN4 channel."
J. Biol. Chem. 285:37082-37091(2010) [PubMed] [Europe PMC] [Abstract]
"Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels."
J. Biol. Chem. 286:44811-44820(2011) [PubMed] [Europe PMC] [Abstract]
"Local and global interpretations of a disease-causing mutation near the ligand entry path in hyperpolarization-activated cAMP-gated channel."
Structure 20:2116-2123(2012) [PubMed] [Europe PMC] [Abstract]
"Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia."
J. Biol. Chem. 279:27194-27198(2004) [PubMed] [Europe PMC] [Abstract]
"Familial sinus bradycardia associated with a mutation in the cardiac pacemaker channel."
N. Engl. J. Med. 354:151-157(2006) [PubMed] [Europe PMC] [Abstract]
"A novel mutation in the HCN4 gene causes symptomatic sinus bradycardia in Moroccan Jews."
J. Cardiovasc. Electrophysiol. 21:1365-1372(2010) [PubMed] [Europe PMC] [Abstract]