Histidine Ammonia Lyase (HAL)
HIS; Histidase
Histidine ammonia-lyase (HAL), also known as histidase (EC 4.3.1.3), is a cytosolic enzyme catalyzing the first reaction in histidine catabolism, the nonoxidative deamination of L-histidine to trans-urocanic acid.
The cDNA predicted a 657-amino acid protein with a molecular mass of approximately 72.6 kD. The authors identified at least 2 different transcription sites, for liver and skin, respectively.By restriction mapping and Southern blot analysis of isolated clones, Suchi et al. (1993) showed that the HAL gene spans approximately 25 kb and consists of 21 exons. Exon 1 encodes only the 5-prime untranslated sequence of liver histidase mRNA, with protein coding beginning in exon 2. A rarely observed 5-prime GC, similar to that reported in CYP11A , a human P-450 gene, is present in intron 20.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO816Hu01 | Recombinant Histidine Ammonia Lyase (HAL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO816Hu01 | Monoclonal Antibody to Histidine Ammonia Lyase (HAL) | WB; IHC; ICC; IP. |
| PAO816Hu01 | Polyclonal Antibody to Histidine Ammonia Lyase (HAL) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO816Hu01 | CLIA Kit for Histidine Ammonia Lyase (HAL) | CLIA assay for Antigen Detection |
| ELO816Hu01 | ELISA Kit for Histidine Ammonia Lyase (HAL) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO816Mu01 | Recombinant Histidine Ammonia Lyase (HAL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO816Mu01 | Monoclonal Antibody to Histidine Ammonia Lyase (HAL) | WB; IHC; ICC; IP. |
| PAO816Mu01 | Polyclonal Antibody to Histidine Ammonia Lyase (HAL) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO816Mu01 | CLIA Kit for Histidine Ammonia Lyase (HAL) | CLIA assay for Antigen Detection |
| ELO816Mu01 | ELISA Kit for Histidine Ammonia Lyase (HAL) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO816Ra01 | Recombinant Histidine Ammonia Lyase (HAL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO816Ra01 | Monoclonal Antibody to Histidine Ammonia Lyase (HAL) | WB; IHC; ICC; IP. |
| PAO816Ra01 | Polyclonal Antibody to Histidine Ammonia Lyase (HAL) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO816Ra01 | CLIA Kit for Histidine Ammonia Lyase (HAL) | CLIA assay for Antigen Detection |
| ELO816Ra01 | ELISA Kit for Histidine Ammonia Lyase (HAL) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO816Ca01 | Recombinant Histidine Ammonia Lyase (HAL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO816Ca01 | Monoclonal Antibody to Histidine Ammonia Lyase (HAL) | WB; IHC; ICC; IP. |
| PAO816Ca01 | Polyclonal Antibody to Histidine Ammonia Lyase (HAL) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO816Ca01 | CLIA Kit for Histidine Ammonia Lyase (HAL) | CLIA assay for Antigen Detection |
| ELO816Ca01 | ELISA Kit for Histidine Ammonia Lyase (HAL) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO816Po01 | Recombinant Histidine Ammonia Lyase (HAL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO816Po01 | Monoclonal Antibody to Histidine Ammonia Lyase (HAL) | WB; IHC; ICC; IP. |
| PAO816Po01 | Polyclonal Antibody to Histidine Ammonia Lyase (HAL) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO816Po01 | CLIA Kit for Histidine Ammonia Lyase (HAL) | CLIA assay for Antigen Detection |
| ELO816Po01 | ELISA Kit for Histidine Ammonia Lyase (HAL) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO816Bo01 | Recombinant Histidine Ammonia Lyase (HAL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO816Bo01 | Monoclonal Antibody to Histidine Ammonia Lyase (HAL) | WB; IHC; ICC; IP. |
| PAO816Bo01 | Polyclonal Antibody to Histidine Ammonia Lyase (HAL) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO816Bo01 | CLIA Kit for Histidine Ammonia Lyase (HAL) | CLIA assay for Antigen Detection |
| ELO816Bo01 | ELISA Kit for Histidine Ammonia Lyase (HAL) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO816Rb01 | Recombinant Histidine Ammonia Lyase (HAL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO816Rb01 | Monoclonal Antibody to Histidine Ammonia Lyase (HAL) | WB; IHC; ICC; IP. |
| PAO816Rb01 | Polyclonal Antibody to Histidine Ammonia Lyase (HAL) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO816Rb01 | CLIA Kit for Histidine Ammonia Lyase (HAL) | CLIA assay for Antigen Detection |
| ELO816Rb01 | ELISA Kit for Histidine Ammonia Lyase (HAL) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO816Mo01 | Recombinant Histidine Ammonia Lyase (HAL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO816Mo01 | Monoclonal Antibody to Histidine Ammonia Lyase (HAL) | WB; IHC; ICC; IP. |
| PAO816Mo01 | Polyclonal Antibody to Histidine Ammonia Lyase (HAL) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO816Mo01 | CLIA Kit for Histidine Ammonia Lyase (HAL) | CLIA assay for Antigen Detection |
| ELO816Mo01 | ELISA Kit for Histidine Ammonia Lyase (HAL) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Molecular cloning of a cDNA encoding human histidase."
Biochim. Biophys. Acta 1216:293-295(1993) [PubMed] [Europe PMC] [Abstract]
"Molecular cloning and structural characterization of the human histidase gene (HAL)."
Genomics 29:98-104(1995) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The finished DNA sequence of human chromosome 12."
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"Molecular characterization of histidinemia: identification of four missense mutations in the histidase gene."
Hum. Genet. 116:340-346(2005) [PubMed] [Europe PMC] [Abstract]