G Protein Alpha Inhibiting Activity Polypeptide 3 (GNaI3)

87U6; Guanine Nucleotide Binding Protein Alpha Inhibiting Activity Polypeptide 3

SPN	O741
HGNC	4387
MGI	95773
PubMed	22560091
RGD	2714
UniProt	P08754
Wiki	GNAI3

Using a cDNA probe against a mouse/human somatic cell hybrid panel, Sparkes et al. (1987) mapped the alpha inhibiting polypeptide-3 of G protein to chromosome 1. Alpha-3 cDNA codes for a protein of 340 amino acids , of which the sequence is closely related to but distinct from that of alpha-2. Wilkie et al. (1992) assigned the gene to 1p13. They assigned the corresponding gene to mouse chromosome 3 by study of restriction fragment length variation in an interspecific backcross. Baron et al. (1994) demonstrated that the Gnai3 gene in the hamster is less than 60 kb from the Ampd2 gene with which it is coamplified in coformycin-resistant cells. The hamster Gnai3 gene did not contain sequences corresponding to the combined U6 snRNA and E protein pseudogene, previously identified within intron 7 of the human gene.

Reference

"Molecular cloning of a new human G protein. Evidence for two Gi alpha-like protein families."
FEBS Lett. 219:259-263(1987) [PubMed] [Europe PMC] [Abstract]

"A small multigene family encodes Gi signal-transduction proteins."
Proc. Natl. Acad. Sci. U.S.A. 84:7886-7890(1987) [PubMed] [Europe PMC] [Abstract]

"Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs."
J. Biol. Chem. 263:6656-6664(1988) [PubMed] [Europe PMC] [Abstract]

"Alpha i-3 cDNA encodes the alpha subunit of Gk, the stimulatory G protein of receptor-regulated K+ channels."
J. Biol. Chem. 263:6746-6750(1988) [PubMed] [Europe PMC] [Abstract]

"Identification of cDNA encoding an additional alpha subunit of a human GTP-binding protein: expression of three alpha i subtypes in human tissues and cell lines."
Proc. Natl. Acad. Sci. U.S.A. 85:4153-4157(1988) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The human genome encodes at least three non-allelic G proteins with alpha i-type subunits."
FEBS Lett. 220:187-192(1987) [PubMed] [Europe PMC] [Abstract]

"Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division."
J. Cell Biol. 178:245-255(2007) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"A human homeotic transformation resulting from mutations in PLCB4 and GNAI3 causes auriculocondylar syndrome."
Am. J. Hum. Genet. 90:907-914(2012) [PubMed] [Europe PMC] [Abstract]

Erratum
Am. J. Hum. Genet. 90:1116-1116(2012)