Guanine Deaminase (GDA)

CYPIN; Guanase; Guanine aminase; Guanine aminohydrolase; p51-nedasin

SPN	O702
HGNC	4212
MGI	95678
PubMed	20716488
RGD	621617
UniProt	Q9Y2T3
Wiki	GDA

Guanine deaminase (GDA) catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.Cypin localizes to both pre- and postsynaptic sites, is enriched in dendritic shafts, cofractionates, and associates with membrane-associated guanylate kinase proteins (PSD95/93 and SAP97/102) in the synaptic plasma membranes and vesicles. Cypin also occurs in the epithelial cells of the small intestine, highest at the tips of the intestinal villi, and exclusively at the basal membrane. GST fusion experiments showed that cypin binding to PSD95 occurs through a C-terminal consensus sequence and requires PDZ domains 1 and 2. Overexpression of cypin in rat hippocampal neurons specifically perturbs postsynaptic trafficking of PSD95 and SAP102 , an effect not produced by overexpression of other PDZ ligands.

Reference

"Cloning and characterization of human guanine deaminase. Purification and partial amino acid sequence of the mouse protein."
J. Biol. Chem. 274:8175-8180(1999) [PubMed] [Europe PMC] [Abstract]

"A novel NE-dlg/SAP102-associated protein, p51-nedasin, related to the amidohydrolase superfamily, interferes with the association between NE-dlg/SAP102 and N-methyl-D-aspartate receptor."
J. Biol. Chem. 274:32204-32214(1999) [PubMed] [Europe PMC] [Abstract]

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Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

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Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]

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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

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"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Human guanine deaminase (GUAD) in complex with zinc and its product xanthine."
Submitted (JAN-2008) to the PDB data bank