Follistatin Like Protein 1 (FSTL1)

FRP; FSL1; Follistatin-related protein 1

SPN	O668
HGNC	3972
MGI	102793
PubMed	23395958
RGD	68955
UniProt	Q12841
Wiki	FSTL1

FSTL1 encodes a protein with similarity to follistatin, an activin-binding protein. It contains an FS module, a follistatin-like sequence containing 10 conserved cysteine residues. This gene product is thought to be an autoantigen associated with rheumatoid arthritis.FSTL1 encodes a deduced 308-amino acid protein with an N-terminal signal peptide of 20 amino acids. The number and distribution of the cysteine residues supports the existence of several intramolecular disulfide bridges.Immunohistochemical analysis demonstrated increased expression in Cd90 (THY1)-positive fibroblasts, particularly early in CIA. Monkey fibroblasts transfected with human FSTL1 spontaneously secreted more IL6, and human monocytes transfected with FSTL1 and stimulated with mitogens expressed higher IL1B, TNF, and IL6.

Reference

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Eur. J. Biochem. 225:937-946(1994) [PubMed] [Europe PMC] [Abstract]

"Cloning of follistatin-related protein as a novel autoantigen in systemic rheumatic diseases."
Int. Immunol. 10:1305-1314(1998) [PubMed] [Europe PMC] [Abstract]

"Follistatin-related protein gene (FRP) is expressed in the synovial tissues of rheumatoid arthritis, but its polymorphisms are not associated with genetic susceptibility."
Clin. Exp. Rheumatol. 22:707-712(2004) [PubMed] [Europe PMC] [Abstract]

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