Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A (DYRK1A)

DYRK; DYRK1; HP86; MNB; MNBH; Dual specificity YAK1-related kinase; Protein kinase minibrain homolog

SPN	O560
HGNC	3091
MGI	1330299
PubMed	24039182
RGD	2528
UniProt	Q13627
Wiki	DYRK1A

DYRK1A encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region.

Reference

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Genomics 38:331-339(1996) [PubMed] [Europe PMC] [Abstract]

"A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical region."
Hum. Mol. Genet. 5:1305-1310(1996) [PubMed] [Europe PMC] [Abstract]

"Cloning of a human homolog of the Drosophila minibrain/rat Dyrk gene from 'the Down syndrome critical region' of chromosome 21."
Biochem. Biophys. Res. Commun. 225:92-99(1996) [PubMed] [Europe PMC] [Abstract]

"Gene identification in 1.6-Mb region of the Down syndrome region on chromosome 21."
Genome Res. 7:47-58(1997) [PubMed] [Europe PMC] [Abstract]

"Human minibrain homologue (MNBH/DYRK1): characterization, alternative splicing, differential tissue expression, and overexpression in Down syndrome."
Genomics 57:407-418(1999) [PubMed] [Europe PMC] [Abstract]

"Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21 involved in Down syndrome."
Genomics 48:12-23(1998) [PubMed] [Europe PMC] [Abstract]

"Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M."
J. Biol. Chem. 278:49573-49581(2003) [PubMed] [Europe PMC] [Abstract]

"Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases."
J. Biol. Chem. 279:2490-2498(2004) [PubMed] [Europe PMC] [Abstract]

"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

"Genome-wide analysis of histidine repeats reveals their role in the localization of human proteins to the nuclear speckles compartment."
PLoS Genet. 5:E1000397-E1000397(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Intragenic deletion in DYRK1A leads to mental retardation and primary microcephaly."
Clin. Genet. 79:296-299(2011) [PubMed] [Europe PMC] [Abstract]

"Splice variants of the dual specificity tyrosine phosphorylation-regulated kinase 4 (DYRK4) differ in their subcellular localization and catalytic activity."
J. Biol. Chem. 286:5494-5505(2011) [PubMed] [Europe PMC] [Abstract]

"Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) modulates serine/arginine-rich protein 55 (SRp55)-promoted Tau exon 10 inclusion."
J. Biol. Chem. 287:30497-30506(2012) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A."
Nat. Commun. 1:86-86(2010) [PubMed] [Europe PMC] [Abstract]

"Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B."
J. Med. Chem. 55:9312-9330(2012) [PubMed] [Europe PMC] [Abstract]

"Pyrido[2,3-d]pyrimidines: discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors."
Bioorg. Med. Chem. Lett. 23:6610-6615(2013) [PubMed] [Europe PMC] [Abstract]

"Structures of Down syndrome kinases, DYRKs, reveal mechanisms of kinase activation and substrate recognition."
Structure 21:986-996(2013) [PubMed] [Europe PMC] [Abstract]

"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]