Delta Like Protein 4 (dLL4)
Hdelta2; Drosophila Delta homolog 4
DLL4 is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain.
The predicted 685-amino acid DLL4 protein exhibits all of the hallmarks of the Delta family of Notch ligands. It has an extracellular region containing 8 EGF-like repeats and a DSL domain involved in Notch binding, as well as a transmembrane domain and a cytoplasmic tail that lacks catalytic motifs. Human DLL4 shares 87% amino acid sequence identity with mouse Dll4. Northern blot analysis of mouse tissues detected highest Dll4 expression in lung, followed by heart, kidney, skeletal muscle, and brain; Dll4 expression was barely detectable in spleen and testis.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO493Hu01 | Recombinant Delta Like Protein 4 (dLL4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO493Hu01 | Monoclonal Antibody to Delta Like Protein 4 (dLL4) | WB; IHC; ICC; IP. |
| PAO493Hu01 | Polyclonal Antibody to Delta Like Protein 4 (dLL4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO493Hu01 | CLIA Kit for Delta Like Protein 4 (dLL4) | CLIA assay for Antigen Detection |
| ELO493Hu01 | ELISA Kit for Delta Like Protein 4 (dLL4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO493Mu01 | Recombinant Delta Like Protein 4 (dLL4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO493Mu01 | Monoclonal Antibody to Delta Like Protein 4 (dLL4) | WB; IHC; ICC; IP. |
| PAO493Mu01 | Polyclonal Antibody to Delta Like Protein 4 (dLL4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO493Mu01 | CLIA Kit for Delta Like Protein 4 (dLL4) | CLIA assay for Antigen Detection |
| ELO493Mu01 | ELISA Kit for Delta Like Protein 4 (dLL4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO493Ra01 | Recombinant Delta Like Protein 4 (dLL4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO493Ra01 | Monoclonal Antibody to Delta Like Protein 4 (dLL4) | WB; IHC; ICC; IP. |
| PAO493Ra01 | Polyclonal Antibody to Delta Like Protein 4 (dLL4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO493Ra01 | CLIA Kit for Delta Like Protein 4 (dLL4) | CLIA assay for Antigen Detection |
| ELO493Ra01 | ELISA Kit for Delta Like Protein 4 (dLL4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO493Ca01 | Recombinant Delta Like Protein 4 (dLL4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO493Ca01 | Monoclonal Antibody to Delta Like Protein 4 (dLL4) | WB; IHC; ICC; IP. |
| PAO493Ca01 | Polyclonal Antibody to Delta Like Protein 4 (dLL4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO493Ca01 | CLIA Kit for Delta Like Protein 4 (dLL4) | CLIA assay for Antigen Detection |
| ELO493Ca01 | ELISA Kit for Delta Like Protein 4 (dLL4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO493Po01 | Recombinant Delta Like Protein 4 (dLL4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO493Po01 | Monoclonal Antibody to Delta Like Protein 4 (dLL4) | WB; IHC; ICC; IP. |
| PAO493Po01 | Polyclonal Antibody to Delta Like Protein 4 (dLL4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO493Po01 | CLIA Kit for Delta Like Protein 4 (dLL4) | CLIA assay for Antigen Detection |
| ELO493Po01 | ELISA Kit for Delta Like Protein 4 (dLL4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO493Bo01 | Recombinant Delta Like Protein 4 (dLL4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO493Bo01 | Monoclonal Antibody to Delta Like Protein 4 (dLL4) | WB; IHC; ICC; IP. |
| PAO493Bo01 | Polyclonal Antibody to Delta Like Protein 4 (dLL4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO493Bo01 | CLIA Kit for Delta Like Protein 4 (dLL4) | CLIA assay for Antigen Detection |
| ELO493Bo01 | ELISA Kit for Delta Like Protein 4 (dLL4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO493Rb01 | Recombinant Delta Like Protein 4 (dLL4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO493Rb01 | Monoclonal Antibody to Delta Like Protein 4 (dLL4) | WB; IHC; ICC; IP. |
| PAO493Rb01 | Polyclonal Antibody to Delta Like Protein 4 (dLL4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO493Rb01 | CLIA Kit for Delta Like Protein 4 (dLL4) | CLIA assay for Antigen Detection |
| ELO493Rb01 | ELISA Kit for Delta Like Protein 4 (dLL4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO493Mo01 | Recombinant Delta Like Protein 4 (dLL4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO493Mo01 | Monoclonal Antibody to Delta Like Protein 4 (dLL4) | WB; IHC; ICC; IP. |
| PAO493Mo01 | Polyclonal Antibody to Delta Like Protein 4 (dLL4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO493Mo01 | CLIA Kit for Delta Like Protein 4 (dLL4) | CLIA assay for Antigen Detection |
| ELO493Mo01 | ELISA Kit for Delta Like Protein 4 (dLL4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Dll4, a novel Notch ligand expressed in arterial endothelium."
Genes Dev. 14:1313-1318(2000) [PubMed] [Europe PMC] [Abstract]
"Molecular cloning of Delta-4, a new mouse and human Notch ligand."
J. Biochem. 129:27-34(2001) [PubMed] [Europe PMC] [Abstract]
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
"A regulatory network involving Foxn4, Mash1 and delta-like 4/Notch1 generates V2a and V2b spinal interneurons from a common progenitor pool."
Development 134:3427-3436(2007) [PubMed] [Europe PMC] [Abstract]
"Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis."
Circ. Res. 107:592-601(2010) [PubMed] [Europe PMC] [Abstract]