D-Amino Acid Oxidase (DAO)

DAMOX

SPN	O448
HGNC	2671
MGI	94859
PubMed	22203986
RGD	621138
UniProt	P14920
Wiki	DAO

DAO encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known; it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia. The biologic role of DAMOX and DASOX has been thought to be protection against L-amino acids of fungi, bacteria and insects, or contribution to acid-base balance in the kidney.

Reference

"Molecular cloning and sequence analysis of cDNA encoding human kidney D-amino acid oxidase."
FEBS Lett. 238:180-184(1988) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning and chromosomal localization of a human gene encoding D-amino-acid oxidase."
J. Biol. Chem. 267:18631-18638(1992) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of human D-amino acid oxidase: context-dependent variability of the backbone conformation of the VAAGL hydrophobic stretch located at the si-face of the flavin ring."
Protein Sci. 15:2708-2717(2006) [PubMed] [Europe PMC] [Abstract]

"Structural basis of D-DOPA oxidation by D-amino acid oxidase: alternative pathway for dopamine biosynthesis."
Biochem. Biophys. Res. Commun. 355:385-391(2007) [PubMed] [Europe PMC] [Abstract]

"The discovery of fused pyrrole carboxylic acids as novel, potent D-amino acid oxidase (DAO) inhibitors."
Bioorg. Med. Chem. Lett. 18:3386-3391(2008) [PubMed] [Europe PMC] [Abstract]