D2-Hydroxyglutarate Dehydrogenase (D2HGDH)
D2HGD
D2HGDH encodes D-2hydroxyglutarate dehydrogenase, a mitochondrial enzyme belonging to the FAD-binding oxidoreductase/transferase type 4 family. This enzyme, which is most active in liver and kidney but also active in heart and brain, converts D-2-hydroxyglutarate to 2-ketoglutarate. Mutations in this gene are present in D-2-hydroxyglutaric aciduria, a rare recessive neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features.
Subcellular fractionation of rat livers indicated that rat D2hgdh was present in the mitochondrial fraction. Assays of D-2-hydroxyglutarate dehydrogenase in rat tissues indicated that this enzyme is most active in liver and kidney but is also active in heart and brain .
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO447Hu01 | Recombinant D2-Hydroxyglutarate Dehydrogenase (D2HGDH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO447Hu01 | Monoclonal Antibody to D2-Hydroxyglutarate Dehydrogenase (D2HGDH) | WB; IHC; ICC; IP. |
| PAO447Hu01 | Polyclonal Antibody to D2-Hydroxyglutarate Dehydrogenase (D2HGDH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO447Hu01 | CLIA Kit for D2-Hydroxyglutarate Dehydrogenase (D2HGDH) | CLIA assay for Antigen Detection |
| ELO447Hu01 | ELISA Kit for D2-Hydroxyglutarate Dehydrogenase (D2HGDH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO447Mu01 | Recombinant D2-Hydroxyglutarate Dehydrogenase (D2HGDH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO447Mu01 | Monoclonal Antibody to D2-Hydroxyglutarate Dehydrogenase (D2HGDH) | WB; IHC; ICC; IP. |
| PAO447Mu01 | Polyclonal Antibody to D2-Hydroxyglutarate Dehydrogenase (D2HGDH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO447Mu01 | CLIA Kit for D2-Hydroxyglutarate Dehydrogenase (D2HGDH) | CLIA assay for Antigen Detection |
| ELO447Mu01 | ELISA Kit for D2-Hydroxyglutarate Dehydrogenase (D2HGDH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO447Ra01 | Recombinant D2-Hydroxyglutarate Dehydrogenase (D2HGDH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO447Ra01 | Monoclonal Antibody to D2-Hydroxyglutarate Dehydrogenase (D2HGDH) | WB; IHC; ICC; IP. |
| PAO447Ra01 | Polyclonal Antibody to D2-Hydroxyglutarate Dehydrogenase (D2HGDH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO447Ra01 | CLIA Kit for D2-Hydroxyglutarate Dehydrogenase (D2HGDH) | CLIA assay for Antigen Detection |
| ELO447Ra01 | ELISA Kit for D2-Hydroxyglutarate Dehydrogenase (D2HGDH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO447Ca01 | Recombinant D2-Hydroxyglutarate Dehydrogenase (D2HGDH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO447Ca01 | Monoclonal Antibody to D2-Hydroxyglutarate Dehydrogenase (D2HGDH) | WB; IHC; ICC; IP. |
| PAO447Ca01 | Polyclonal Antibody to D2-Hydroxyglutarate Dehydrogenase (D2HGDH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO447Ca01 | CLIA Kit for D2-Hydroxyglutarate Dehydrogenase (D2HGDH) | CLIA assay for Antigen Detection |
| ELO447Ca01 | ELISA Kit for D2-Hydroxyglutarate Dehydrogenase (D2HGDH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO447Po01 | Recombinant D2-Hydroxyglutarate Dehydrogenase (D2HGDH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO447Po01 | Monoclonal Antibody to D2-Hydroxyglutarate Dehydrogenase (D2HGDH) | WB; IHC; ICC; IP. |
| PAO447Po01 | Polyclonal Antibody to D2-Hydroxyglutarate Dehydrogenase (D2HGDH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO447Po01 | CLIA Kit for D2-Hydroxyglutarate Dehydrogenase (D2HGDH) | CLIA assay for Antigen Detection |
| ELO447Po01 | ELISA Kit for D2-Hydroxyglutarate Dehydrogenase (D2HGDH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO447Bo01 | Recombinant D2-Hydroxyglutarate Dehydrogenase (D2HGDH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO447Bo01 | Monoclonal Antibody to D2-Hydroxyglutarate Dehydrogenase (D2HGDH) | WB; IHC; ICC; IP. |
| PAO447Bo01 | Polyclonal Antibody to D2-Hydroxyglutarate Dehydrogenase (D2HGDH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO447Bo01 | CLIA Kit for D2-Hydroxyglutarate Dehydrogenase (D2HGDH) | CLIA assay for Antigen Detection |
| ELO447Bo01 | ELISA Kit for D2-Hydroxyglutarate Dehydrogenase (D2HGDH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO447Rb01 | Recombinant D2-Hydroxyglutarate Dehydrogenase (D2HGDH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO447Rb01 | Monoclonal Antibody to D2-Hydroxyglutarate Dehydrogenase (D2HGDH) | WB; IHC; ICC; IP. |
| PAO447Rb01 | Polyclonal Antibody to D2-Hydroxyglutarate Dehydrogenase (D2HGDH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO447Rb01 | CLIA Kit for D2-Hydroxyglutarate Dehydrogenase (D2HGDH) | CLIA assay for Antigen Detection |
| ELO447Rb01 | ELISA Kit for D2-Hydroxyglutarate Dehydrogenase (D2HGDH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO447Mo01 | Recombinant D2-Hydroxyglutarate Dehydrogenase (D2HGDH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO447Mo01 | Monoclonal Antibody to D2-Hydroxyglutarate Dehydrogenase (D2HGDH) | WB; IHC; ICC; IP. |
| PAO447Mo01 | Polyclonal Antibody to D2-Hydroxyglutarate Dehydrogenase (D2HGDH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO447Mo01 | CLIA Kit for D2-Hydroxyglutarate Dehydrogenase (D2HGDH) | CLIA assay for Antigen Detection |
| ELO447Mo01 | ELISA Kit for D2-Hydroxyglutarate Dehydrogenase (D2HGDH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Identification of a dehydrogenase acting on D-2-hydroxyglutarate."
Biochem. J. 381:35-42(2004) [PubMed] [Europe PMC] [Abstract]
"Mutations in the D-2-hydroxyglutarate dehydrogenase gene cause D-2-hydroxyglutaric aciduria."
Am. J. Hum. Genet. 76:358-360(2005) [PubMed] [Europe PMC] [Abstract]
"Mutations in phenotypically mild D-2-hydroxyglutaric aciduria."
Ann. Neurol. 58:626-630(2005) [PubMed] [Europe PMC] [Abstract]
"Phenotypic heterogeneity in the presentation of D-2-hydroxyglutaric aciduria in monozygotic twins."
Mol. Genet. Metab. 86:200-205(2005) [PubMed] [Europe PMC] [Abstract]
"D-2-Hydroxyglutaric aciduria in three patients with proven SSADH deficiency: genetic coincidence or a related biochemical epiphenomenon?"
Mol. Genet. Metab. 88:53-57(2006) [PubMed] [Europe PMC] [Abstract]