Cancer/Testis Antigen 1B (CTAG1B)

CTAG; CTAG1; ESO1; LAGE-2; LAGE2B; NY-ESO-1; CAMEL; ESO2; LAGE-1; LAGE-2b; LAGE2A; Autoimmunogenic cancer/testis antigen NY-ESO-1; L antigen family member 2

SPN	O430
HGNC	2491
PubMed	22936067
UniProt	P78358
Wiki	CTAG1B

Cancer/testis antigens, such as CTAG1B, are expressed in a variety of malignant tumors but soley in testis among normal adult tissues.

NYESO1 expression in primary MTC tissues significantly correlated with tumor recurrence. The presence of specific anti-NYESO1 antibodies was searched in the sera of MTC-affected patients examined by ELISA using recombinant NYESO1 protein. A humoral response against this CTA was detected in 6 of 11 NYESO1-expressing patients (54.5%), and in 1 of 6 patients with an NYESO1-negative tumor. Anti-NYESO1 antibodies were present in 15 of 42 sera (35.7%), demonstrating that MTC is a neoplasm frequently associated with humoral immune response to NYESO1.

Reference

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"DNA methylation is the primary silencing mechanism for a set of germ line- and tumor-specific genes with a CpG-rich promoter."
Mol. Cell. Biol. 19:7327-7335(1999) [PubMed] [Europe PMC] [Abstract]

"Multiple pathogenic and benign genomic rearrangements occur at a 35 kb duplication involving the NEMO and LAGE2 genes."
Hum. Mol. Genet. 10:2557-2567(2001) [PubMed] [Europe PMC] [Abstract]

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Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]

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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The cancer-testis gene, NY-ESO-1, is expressed in normal fetal and adult testes and in spermatocytic seminomas and testicular carcinoma in situ."
Lab. Invest. 82:775-780(2002) [PubMed] [Europe PMC] [Abstract]

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J. Exp. Med. 201:1243-1255(2005) [PubMed] [Europe PMC] [Abstract]