Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1)
Cysteine-Rich Motor neuron 1; Chordin-Like; Cysteine-rich repeat-containing protein S52
Motor neurons are among the earliest neurons to appear after the commencement of cell patterning and the beginning of cell differentiation. Differentiation occurs in a ventral-to-dorsal gradient and is mediated, at least in part, by the concentration of ventrally expressed sonic hedgehog protein (SHH). Dorsally expressed factors, such as members of the bone morphogenic protein and transforming growth factor-beta families, can repress the induction of these neurons.
CRIM1 may interact with growth factors implicated in motor neuron differentiation and survival . Expressed in pancreas, kidney, skeletal muscle, lung, placenta, brain, heart, spleen, liver and small intestine. Expressed in blood vessels (at protein level).
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO403Hu01 | Recombinant Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO403Hu01 | Monoclonal Antibody to Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1) | WB; IHC; ICC; IP. |
| PAO403Hu01 | Polyclonal Antibody to Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO403Hu01 | CLIA Kit for Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1) | CLIA assay for Antigen Detection |
| ELO403Hu01 | ELISA Kit for Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO403Mu01 | Recombinant Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO403Mu01 | Monoclonal Antibody to Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1) | WB; IHC; ICC; IP. |
| PAO403Mu01 | Polyclonal Antibody to Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO403Mu01 | CLIA Kit for Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1) | CLIA assay for Antigen Detection |
| ELO403Mu01 | ELISA Kit for Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO403Ra01 | Recombinant Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO403Ra01 | Monoclonal Antibody to Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1) | WB; IHC; ICC; IP. |
| PAO403Ra01 | Polyclonal Antibody to Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO403Ra01 | CLIA Kit for Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1) | CLIA assay for Antigen Detection |
| ELO403Ra01 | ELISA Kit for Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO403Ca01 | Recombinant Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO403Ca01 | Monoclonal Antibody to Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1) | WB; IHC; ICC; IP. |
| PAO403Ca01 | Polyclonal Antibody to Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO403Ca01 | CLIA Kit for Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1) | CLIA assay for Antigen Detection |
| ELO403Ca01 | ELISA Kit for Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO403Po01 | Recombinant Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO403Po01 | Monoclonal Antibody to Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1) | WB; IHC; ICC; IP. |
| PAO403Po01 | Polyclonal Antibody to Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO403Po01 | CLIA Kit for Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1) | CLIA assay for Antigen Detection |
| ELO403Po01 | ELISA Kit for Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO403Bo01 | Recombinant Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO403Bo01 | Monoclonal Antibody to Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1) | WB; IHC; ICC; IP. |
| PAO403Bo01 | Polyclonal Antibody to Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO403Bo01 | CLIA Kit for Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1) | CLIA assay for Antigen Detection |
| ELO403Bo01 | ELISA Kit for Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO403Rb01 | Recombinant Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO403Rb01 | Monoclonal Antibody to Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1) | WB; IHC; ICC; IP. |
| PAO403Rb01 | Polyclonal Antibody to Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO403Rb01 | CLIA Kit for Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1) | CLIA assay for Antigen Detection |
| ELO403Rb01 | ELISA Kit for Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO403Mo01 | Recombinant Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO403Mo01 | Monoclonal Antibody to Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1) | WB; IHC; ICC; IP. |
| PAO403Mo01 | Polyclonal Antibody to Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO403Mo01 | CLIA Kit for Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1) | CLIA assay for Antigen Detection |
| ELO403Mo01 | ELISA Kit for Cysteine Rich Transmembrane BMP Regulator 1 (CRIM1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis."
Mech. Dev. 90:181-193(2000) [PubMed] [Europe PMC] [Abstract]
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"CRIM1 regulates the rate of processing and delivery of bone morphogenetic proteins to the cell surface."
J. Biol. Chem. 278:34181-34188(2003) [PubMed] [Europe PMC] [Abstract]
"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
"CRIM1 is involved in endothelial cell capillary formation in vitro and is expressed in blood vessels in vivo."
Mech. Dev. 119:165-175(2002) [PubMed] [Europe PMC] [Abstract]
"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]