Calponin 2 (CNN2)

Neutral calponin; Calponin H2, smooth muscle

SPN	O329
HGNC	2156
MGI	105093
PubMed	23499442
UniProt	Q99439

Calponin 2, which can bind actin, calmodulin, troponin C, and tropomyosin, may function in the structural organization of actin filaments. The encoded protein could play a role in smooth muscle contraction and cell adhesion. Two transcript variants encoding different isoforms have been found for this gene.

The CNN2 protein is 94.8% identical to mouse calponin h2, indicating that these proteins are homologs. The predicted CNN2 protein has 309 amino acids and a pI of 7.1. It contains motifs that are present in CNN1 and CNN3: 3 tandem repeats of 29 amino acids, an actin-binding domain, a VAV-homologous region, and 2 consensus phosphorylation sites for tyrosine kinase at the C terminus. The 3-prime untranslated region of the CNN2 mRNA contains an Alu repetitive sequence in the antisense direction.

Reference

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Submitted (AUG-2005) to the PDB data bank