Calponin 1, Basic (CNN1)
SMCC; Sm-Calp; Smooth Muscle Cell Calponin
Calponin is a basic 34-kD protein first isolated from chicken gizzard and bovine aorta. It is specifically expressed in smooth muscle and binds calmodulin, actin, and tropomyosin. It is able to inhibit the ATPase activity of myosin and is thought to play a role in smooth muscle contraction. These are the products of separate loci. Northern blots of mouse uterus RNA indicated that h1 transcripts are about 10-fold higher than those of the h2 gene.
The 297-amino acid CNN1 contains a motif that is tandemly repeated 3 times. The N terminus of CNN1 is markedly basic and highly homologous to that of CNN3. CNN1 has a predicted pI of 9.4. Northern blot analysis of RNA from human tissues showed that CNN1 is specifically expressed in smooth muscle.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO328Hu01 | Recombinant Calponin 1, Basic (CNN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO328Hu01 | Monoclonal Antibody to Calponin 1, Basic (CNN1) | WB; IHC; ICC; IP. |
| PAO328Hu01 | Polyclonal Antibody to Calponin 1, Basic (CNN1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO328Hu01 | CLIA Kit for Calponin 1, Basic (CNN1) | CLIA assay for Antigen Detection |
| ELO328Hu01 | ELISA Kit for Calponin 1, Basic (CNN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO328Mu01 | Recombinant Calponin 1, Basic (CNN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO328Mu01 | Monoclonal Antibody to Calponin 1, Basic (CNN1) | WB; IHC; ICC; IP. |
| PAO328Mu01 | Polyclonal Antibody to Calponin 1, Basic (CNN1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO328Mu01 | CLIA Kit for Calponin 1, Basic (CNN1) | CLIA assay for Antigen Detection |
| ELO328Mu01 | ELISA Kit for Calponin 1, Basic (CNN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO328Ra01 | Recombinant Calponin 1, Basic (CNN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO328Ra01 | Monoclonal Antibody to Calponin 1, Basic (CNN1) | WB; IHC; ICC; IP. |
| PAO328Ra01 | Polyclonal Antibody to Calponin 1, Basic (CNN1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO328Ra01 | CLIA Kit for Calponin 1, Basic (CNN1) | CLIA assay for Antigen Detection |
| ELO328Ra01 | ELISA Kit for Calponin 1, Basic (CNN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO328Ca01 | Recombinant Calponin 1, Basic (CNN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO328Ca01 | Monoclonal Antibody to Calponin 1, Basic (CNN1) | WB; IHC; ICC; IP. |
| PAO328Ca01 | Polyclonal Antibody to Calponin 1, Basic (CNN1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO328Ca01 | CLIA Kit for Calponin 1, Basic (CNN1) | CLIA assay for Antigen Detection |
| ELO328Ca01 | ELISA Kit for Calponin 1, Basic (CNN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO328Po01 | Recombinant Calponin 1, Basic (CNN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO328Po01 | Monoclonal Antibody to Calponin 1, Basic (CNN1) | WB; IHC; ICC; IP. |
| PAO328Po01 | Polyclonal Antibody to Calponin 1, Basic (CNN1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO328Po01 | CLIA Kit for Calponin 1, Basic (CNN1) | CLIA assay for Antigen Detection |
| ELO328Po01 | ELISA Kit for Calponin 1, Basic (CNN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO328Bo01 | Recombinant Calponin 1, Basic (CNN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO328Bo01 | Monoclonal Antibody to Calponin 1, Basic (CNN1) | WB; IHC; ICC; IP. |
| PAO328Bo01 | Polyclonal Antibody to Calponin 1, Basic (CNN1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO328Bo01 | CLIA Kit for Calponin 1, Basic (CNN1) | CLIA assay for Antigen Detection |
| ELO328Bo01 | ELISA Kit for Calponin 1, Basic (CNN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO328Rb01 | Recombinant Calponin 1, Basic (CNN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO328Rb01 | Monoclonal Antibody to Calponin 1, Basic (CNN1) | WB; IHC; ICC; IP. |
| PAO328Rb01 | Polyclonal Antibody to Calponin 1, Basic (CNN1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO328Rb01 | CLIA Kit for Calponin 1, Basic (CNN1) | CLIA assay for Antigen Detection |
| ELO328Rb01 | ELISA Kit for Calponin 1, Basic (CNN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPO328Mo01 | Recombinant Calponin 1, Basic (CNN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAO328Mo01 | Monoclonal Antibody to Calponin 1, Basic (CNN1) | WB; IHC; ICC; IP. |
| PAO328Mo01 | Polyclonal Antibody to Calponin 1, Basic (CNN1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLO328Mo01 | CLIA Kit for Calponin 1, Basic (CNN1) | CLIA assay for Antigen Detection |
| ELO328Mo01 | ELISA Kit for Calponin 1, Basic (CNN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Molecular cloning and gene mapping of human basic and acidic calponins."
Biochem. Biophys. Res. Commun. 217:238-244(1995) [PubMed] [Europe PMC] [Abstract]
"Expression, genomic structure and high resolution mapping to 19p13.2 of the human smooth muscle cell calponin gene."
Gene 197:215-224(1997) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Solution structure of the CH domain of human calponin 1."
Submitted (AUG-2005) to the PDB data bank