Chromatin Assembly Factor 1, Subunit B (CHAF1B)

CAF-1; CAF-IP60; CAF1; CAF1A; CAF1P60; MPHOSPH7; MPP7; M-Phase Phosphoprotein 7; Chromatin Assembly Factor I,p60 subunit; M-phase phosphoprotein 7

SPN	O304
HGNC	1911
MGI	1314881
PubMed	7600578
RGD	1307634
UniProt	Q13112
Wiki	CHAF1B

CHAF1B corresponds to the p60 subunit and is required for chromatin assembly after replication. The encoded protein is differentially phosphorylated in a cell cycle-dependent manner. In addition, it is normally found in the nucleus except during mitosis, when it is released into the cytoplasm. This protein is a member of the WD-repeat HIR1 family and may also be involved in DNA repair. The predicted 559-amino acid protein belongs to the WD (tryptophan-aspartate), or transducin, family. These proteins are generally characterized by 4 to 8 copies of a repeat of approximately 40 residues that often ends with a WD sequence (p60 has 7 copies of the motif). The p60 subunit also has a PEST (proline-glutamic acid-serine-threonine) box at its C terminus that is associated with proteins of short half-lives.

Reference

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