Bcl2/Adenovirus E1B 19kDa Interacting Protein 3 (BNIP3)

NIP3

SPN	O214
HGNC	1084
MGI	109326
PubMed	22292033
RGD	1565371
UniProt	Q12983
Wiki	BNIP3

BNIP3 is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein which is responsible for the protection of virally-induced cell death, as well as E1B 19 kDa-like sequences of BCL2, also an apoptotic protector. This gene contains a BH3 domain and a transmembrane domain, which have been associated with pro-apoptotic function.

The NIP3 protein has 194 amino acids and contains a putative membrane-spanning hydrophobic domain. Although the NIP3 cDNA sequence is highly homologous to a rat cDNA that encodes the rat brain calbindin-D protein, the authors determined that the NIP3 protein is encoded by a unique mRNA in human cells.

Reference

"Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins."
Cell 79:341-351(1994) [PubMed] [Europe PMC] [Abstract]

"The E1B 19K/Bcl-2-binding protein Nip3 is a dimeric mitochondrial protein that activates apoptosis."
J. Exp. Med. 186:1975-1983(1997) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 10."
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region."
Cell Death Differ. 6:314-325(1999) [PubMed] [Europe PMC] [Abstract]

"Acetyl-Coenzyme A acyltransferase 2 attenuates the apoptotic effects of BNIP3 in two human cell lines."
Biochim. Biophys. Acta 1780:873-880(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3."
Cell Res. 20:314-331(2010) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"BNIP3 and NIX mediate Mieap-induced accumulation of lysosomal proteins within mitochondria."
PLoS ONE 7:E30767-E30767(2012) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]