Beclin 1 (BECN1)

ATG6; VPS30; Coiled-Coil,Myosin-Like BCL2 Interacting Protein; ATG6 Autophagy Related 6 Homolog

SPN	O202
HGNC	1034
MGI	1891828
PubMed	23681223
RGD	620190
UniProt	Q14457
Wiki	BECN1

Beclin-1 is also known as autophagy-related gene (Atg) 6. Beclin-1 and its binding partner class III phosphoinositide 3-kinase (PI3K), also named Vps34, are required for the initiation of the formation of the autophagasome in autophagy.Human beclin encodes a novel 450-amino acid protein containing a coiled-coil region, within which it has limited homology to myosin-like proteins . Human and mouse beclin share 98% amino acid sequence identity. Caenorhabditis elegans and Saccharomyces cerevisiae beclin homologs were also identified. PROSITE analysis of human beclin detected several potential glycosylation, phosphorylation, and myristoylation sites, but no other functional sequence motifs. Northern blot analysis of mouse and adult human tissues revealed widespread beclin expression.

Reference

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J. Virol. 72:8586-8596(1998) [PubMed] [Europe PMC] [Abstract]

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Genomics 59:59-65(1999) [PubMed] [Europe PMC] [Abstract]

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Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21."
Genomics 28:530-542(1995) [PubMed] [Europe PMC] [Abstract]

"Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG."
Mol. Biol. Cell 19:5360-5372(2008) [PubMed] [Europe PMC] [Abstract]

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

"Reduced expression of vacuole membrane protein 1 affects the invasion capacity of tumor cells."
Oncogene 27:1320-1326(2008) [PubMed] [Europe PMC] [Abstract]

"Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase."
Proc. Natl. Acad. Sci. U.S.A. 105:19211-19216(2008) [PubMed] [Europe PMC] [Abstract]

"DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy."
EMBO Rep. 10:285-292(2009) [PubMed] [Europe PMC] [Abstract]

"Large-scale proteomics analysis of the human kinome."
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

"Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages."
Nat. Cell Biol. 11:385-396(2009) [PubMed] [Europe PMC] [Abstract]

"PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody."
Nat. Cell Biol. 12:362-371(2010) [PubMed] [Europe PMC] [Abstract]

"Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13."
Cell 147:223-234(2011) [PubMed] [Europe PMC] [Abstract]

"Nedd4-dependent lysine-11-linked polyubiquitination of the tumour suppressor Beclin 1."
Biochem. J. 441:399-406(2012) [PubMed] [Europe PMC] [Abstract]

"The human cytomegalovirus protein TRS1 inhibits autophagy via its interaction with Beclin 1."
J. Virol. 86:2571-2584(2012) [PubMed] [Europe PMC] [Abstract]

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

"XBP1 mRNA splicing triggers an autophagic response in endothelial cells through BECLIN-1 transcriptional activation."
J. Biol. Chem. 288:859-872(2013) [PubMed] [Europe PMC] [Abstract]

"Role of membrane association and Atg14-dependent phosphorylation in beclin-1-mediated autophagy."
Mol. Cell. Biol. 33:3675-3688(2013) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein."
J. Biol. Chem. 282:13123-13132(2007) [PubMed] [Europe PMC] [Abstract]

"Molecular basis of Bcl-xL's target recognition versatility revealed by the structure of Bcl-xL in complex with the BH3 domain of beclin-1."
J. Mol. Biol. 372:223-235(2007) [PubMed] [Europe PMC] [Abstract]