Anillin (ANLN)

Scra; Scraps; Actin-Binding Protein Anillin

SPN	O124
HGNC	14082
MGI	1920174
PubMed	7559773
RGD	1566097
UniProt	Q9NQW6
Wiki	ANLN

Anillin migrates at 190 kD on SDS-PAGE. Anillin is expressed throughout Drosophila development and in tissue culture cells. In contractile rings, metaphase furrows, and nascent ring canals, anillin remains bound to the invaginated cortex suggesting a stabilizing role. Anillin is not expressed in cells that have left the cell cycle. Anillin isolated from embryo extracts binds directly to actin filaments. The domain responsible for this binding has been mapped to a region of 244 amino acids by expression of protein fragments in bacteria. This domain, which is monomeric in solution, also bundles actin filaments. Anillin plays a role in organizing and/or stabilizing the cleavage furrow and other cell cycle regulated, contractile domains of the actin cytoskeleton.

Reference

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"Mutations in the gene that encodes the F-actin binding protein anillin cause FSGS."
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