Amelogenin, X-Linked (AMELX)

AMGX; AIH1; ALGN; AMG; AMGL; Amelogenesis Imperfecta 1

SPN	O119
HGNC	461
MGI	88005
PubMed	22221294
RGD	2107
UniProt	Q99217
Wiki	AMELX

Amelogenin, X isoform is a form of amelogenin found on the X chromosome.Amelogenin X is a member of the amelogenin family of extracellular matrix proteins. When alternative splicing occurs it results in multiple transcript variants encoding different isoforms.

Amelogenins are highly conserved proteins secreted by ameloblasts, and constitute 90% of the enamel organic matrix. As the proteins are digested and removed, the mineral crystals grow in well-organized prism patterns . The sequences were homologous to previously sequenced cDNA clones of mouse and cattle encoding amelogenin. Three exons were identified in both the X and the Y sequences.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPO119Hu01	Recombinant Amelogenin, X-Linked (AMELX)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAO119Hu01	Monoclonal Antibody to Amelogenin, X-Linked (AMELX)	WB; IHC; ICC; IP.
Antibodies	PAO119Hu01	Polyclonal Antibody to Amelogenin, X-Linked (AMELX)	WB; IHC; ICC; IF.
Assay Kits	CLO119Hu01	CLIA Kit for Amelogenin, X-Linked (AMELX)	CLIA assay for Antigen Detection
Assay Kits	ELO119Hu01	ELISA Kit for Amelogenin, X-Linked (AMELX)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPO119Mu01	Recombinant Amelogenin, X-Linked (AMELX)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAO119Mu01	Monoclonal Antibody to Amelogenin, X-Linked (AMELX)	WB; IHC; ICC; IP.
Antibodies	PAO119Mu01	Polyclonal Antibody to Amelogenin, X-Linked (AMELX)	WB; IHC; ICC; IF.
Assay Kits	CLO119Mu01	CLIA Kit for Amelogenin, X-Linked (AMELX)	CLIA assay for Antigen Detection
Assay Kits	ELO119Mu01	ELISA Kit for Amelogenin, X-Linked (AMELX)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPO119Ra01	Recombinant Amelogenin, X-Linked (AMELX)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAO119Ra01	Monoclonal Antibody to Amelogenin, X-Linked (AMELX)	WB; IHC; ICC; IP.
Antibodies	PAO119Ra01	Polyclonal Antibody to Amelogenin, X-Linked (AMELX)	WB; IHC; ICC; IF.
Assay Kits	CLO119Ra01	CLIA Kit for Amelogenin, X-Linked (AMELX)	CLIA assay for Antigen Detection
Assay Kits	ELO119Ra01	ELISA Kit for Amelogenin, X-Linked (AMELX)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPO119Ca01	Recombinant Amelogenin, X-Linked (AMELX)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAO119Ca01	Monoclonal Antibody to Amelogenin, X-Linked (AMELX)	WB; IHC; ICC; IP.
Antibodies	PAO119Ca01	Polyclonal Antibody to Amelogenin, X-Linked (AMELX)	WB; IHC; ICC; IF.
Assay Kits	CLO119Ca01	CLIA Kit for Amelogenin, X-Linked (AMELX)	CLIA assay for Antigen Detection
Assay Kits	ELO119Ca01	ELISA Kit for Amelogenin, X-Linked (AMELX)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPO119Po01	Recombinant Amelogenin, X-Linked (AMELX)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAO119Po01	Monoclonal Antibody to Amelogenin, X-Linked (AMELX)	WB; IHC; ICC; IP.
Antibodies	PAO119Po01	Polyclonal Antibody to Amelogenin, X-Linked (AMELX)	WB; IHC; ICC; IF.
Assay Kits	CLO119Po01	CLIA Kit for Amelogenin, X-Linked (AMELX)	CLIA assay for Antigen Detection
Assay Kits	ELO119Po01	ELISA Kit for Amelogenin, X-Linked (AMELX)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPO119Bo01	Recombinant Amelogenin, X-Linked (AMELX)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAO119Bo01	Monoclonal Antibody to Amelogenin, X-Linked (AMELX)	WB; IHC; ICC; IP.
Antibodies	PAO119Bo01	Polyclonal Antibody to Amelogenin, X-Linked (AMELX)	WB; IHC; ICC; IF.
Assay Kits	CLO119Bo01	CLIA Kit for Amelogenin, X-Linked (AMELX)	CLIA assay for Antigen Detection
Assay Kits	ELO119Bo01	ELISA Kit for Amelogenin, X-Linked (AMELX)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPO119Rb01	Recombinant Amelogenin, X-Linked (AMELX)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAO119Rb01	Monoclonal Antibody to Amelogenin, X-Linked (AMELX)	WB; IHC; ICC; IP.
Antibodies	PAO119Rb01	Polyclonal Antibody to Amelogenin, X-Linked (AMELX)	WB; IHC; ICC; IF.
Assay Kits	CLO119Rb01	CLIA Kit for Amelogenin, X-Linked (AMELX)	CLIA assay for Antigen Detection
Assay Kits	ELO119Rb01	ELISA Kit for Amelogenin, X-Linked (AMELX)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPO119Mo01	Recombinant Amelogenin, X-Linked (AMELX)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAO119Mo01	Monoclonal Antibody to Amelogenin, X-Linked (AMELX)	WB; IHC; ICC; IP.
Antibodies	PAO119Mo01	Polyclonal Antibody to Amelogenin, X-Linked (AMELX)	WB; IHC; ICC; IF.
Assay Kits	CLO119Mo01	CLIA Kit for Amelogenin, X-Linked (AMELX)	CLIA assay for Antigen Detection
Assay Kits	ELO119Mo01	ELISA Kit for Amelogenin, X-Linked (AMELX)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"The human enamel protein gene amelogenin is expressed from both the X and the Y chromosomes."
Am. J. Hum. Genet. 50:303-316(1992) [PubMed] [Europe PMC] [Abstract]

"A nomenclature for X-linked amelogenesis imperfecta."
Arch. Oral Biol. 47:255-260(2002) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of the human X chromosome."
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Human amelogenins: sequences of 'TRAP' molecules."
Calcif. Tissue Int. 45:243-250(1989) [PubMed] [Europe PMC] [Abstract]

"Production of a monoclonal antibody against human amelogenin."
Calcif. Tissue Int. 54:76-80(1994) [PubMed] [Europe PMC] [Abstract]

"A human X-Y homologous region encodes 'amelogenin'."
Genomics 9:264-269(1991) [PubMed] [Europe PMC] [Abstract]

"Amino acid sequence of a major human amelogenin protein employing Edman degradation and cDNA sequencing."
J. Dent. Res. 72:1566-1572(1993) [PubMed] [Europe PMC] [Abstract]

"Amelogenin signal peptide mutation: correlation between mutations in the amelogenin gene (AMGX) and manifestations of X-linked amelogenesis imperfecta."
Genomics 26:159-162(1995) [PubMed] [Europe PMC] [Abstract]

"Characterisation of molecular defects in X-linked amelogenesis imperfecta (AIH1)."
Hum. Mutat. 5:251-259(1995) [PubMed] [Europe PMC] [Abstract]

"Mutational analysis of X-linked amelogenesis imperfecta in multiple families."
Arch. Oral Biol. 45:79-86(2000) [PubMed] [Europe PMC] [Abstract]

"An amelogenin gene defect associated with human X-linked amelogenesis imperfecta."
Arch. Oral Biol. 42:235-242(1997) [PubMed] [Europe PMC] [Abstract]

"Amelogenin p.M1T and p.W4S mutations underlying hypoplastic X-linked amelogenesis imperfecta."
J. Dent. Res. 83:378-383(2004) [PubMed] [Europe PMC] [Abstract]