Aryl Hydrocarbon Receptor Repressor (AHRR)

AHH; AHHR; BHLHE77; Aryl Hydrocarbon Receptor Regulator; Class E basic helix-loop-helix protein 77

SPN	O104
HGNC	346
MGI	1333776
PubMed	22337624
RGD	1559857
UniProt	Q9ULI6
Wiki	AHRR

AHRR represses signal transduction by the arylhydrocarbon receptor by competing with the arylhydrocarbon receptor nuclear translocator for binding to the arylhydrocarbon receptor. Expression of the repressor is stimulated by the receptor/translocator heterodimer, thereby regulating receptor function through a negative feedback mechanism. In addition, the encoded protein can bind to nuclear factor kappa-B.

Mouse Ahrr inhibited Ahr function by competing with Ahr for dimerizing with Arnt and binding to the XRE. expression of Ahrr was induced by the Ahr-Arnt heterodimer when the latter bound to the XRE of Ahrr, i.e., Ahrr regulated Ahr function by negative feedback and affected expression of target genes induced by dioxin.

Reference

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Teratology 65:10-18(2002) [PubMed] [Europe PMC] [Abstract]

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Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Characteristic expression of aryl hydrocarbon receptor repressor gene in human tissues: organ-specific distribution and variable induction patterns in mononuclear cells."
Life Sci. 74:1039-1049(2004) [PubMed] [Europe PMC] [Abstract]

"Identification of intracellular localization signals and of mechanisms underlining the nucleocytoplasmic shuttling of human aryl hydrocarbon receptor repressor."
Biochem. Biophys. Res. Commun. 364:1026-1031(2007) [PubMed] [Europe PMC] [Abstract]

"Analysis of the transcriptional regulation and molecular function of the aryl hydrocarbon receptor repressor in human cell lines."
Drug Metab. Dispos. 35:2262-2269(2007) [PubMed] [Europe PMC] [Abstract]

"The aryl hydrocarbon receptor repressor is a putative tumor suppressor gene in multiple human cancers."
J. Clin. Invest. 118:640-650(2008) [PubMed] [Europe PMC] [Abstract]

"Association of male infertility with Pro185Ala polymorphism in the aryl hydrocarbon receptor repressor gene: implication for the susceptibility to dioxins."
Fertil. Steril. 82:1067-1071(2004) [PubMed] [Europe PMC] [Abstract]

"Analysis of the AhR, ARNT, and AhRR gene polymorphisms: genetic contribution to endometriosis susceptibility and severity."
Fertil. Steril. 84:454-458(2005) [PubMed] [Europe PMC] [Abstract]

"The contribution of genetic variations of aryl hydrocarbon receptor pathway genes to male factor infertility."
Fertil. Steril. 88:854-859(2007) [PubMed] [Europe PMC] [Abstract]