Transcription Factor Binding To IGHM Enhancer 3 (TFE3)

RCCP2; TFEA; BHLHE33; Transcription Tactor E Family Member A; Class E basic helix-loop-helix protein 33; Transcription factor E3

SPN	O045
HGNC	11752
MGI	98511
PubMed	23885019
RGD	1559642
UniProt	P19532
Wiki	TFE3

TEF3 activates transcription through binding to the muE3 motif of the immunoglobulin heavy-chain enhancer. The TFEC protein forms heterodimers with the TEF3 protein and inhibits TFE3-dependent transcription activation. The TEF3 protein interacts with transcription regulators such as E2F3, SMAD3, and LEF-1, and is involved in TGF-beta-induced transcription, playing important roles in cell growth, proliferation, and osteoclast and macrophage differentiation. The TFE3 protein also activates hepatic IRS-2 gene, and induces hexokinase II (HK2) and insulin-induced gene 1 (INSIG1); it participates in insulin signaling and could be a therapeutic target for diabetes. This gene is also involved in chromosomal translocations, resulting in different fusion gene products in papillary renal cell carcinomas and alveolar soft part sarcomas.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPO045Hu01	Recombinant Transcription Factor Binding To IGHM Enhancer 3 (TFE3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAO045Hu01	Monoclonal Antibody to Transcription Factor Binding To IGHM Enhancer 3 (TFE3)	WB; IHC; ICC; IP.
Antibodies	PAO045Hu01	Polyclonal Antibody to Transcription Factor Binding To IGHM Enhancer 3 (TFE3)	WB; IHC; ICC; IF.
Assay Kits	CLO045Hu01	CLIA Kit for Transcription Factor Binding To IGHM Enhancer 3 (TFE3)	CLIA assay for Antigen Detection
Assay Kits	ELO045Hu01	ELISA Kit for Transcription Factor Binding To IGHM Enhancer 3 (TFE3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPO045Mu01	Recombinant Transcription Factor Binding To IGHM Enhancer 3 (TFE3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAO045Mu01	Monoclonal Antibody to Transcription Factor Binding To IGHM Enhancer 3 (TFE3)	WB; IHC; ICC; IP.
Antibodies	PAO045Mu01	Polyclonal Antibody to Transcription Factor Binding To IGHM Enhancer 3 (TFE3)	WB; IHC; ICC; IF.
Assay Kits	CLO045Mu01	CLIA Kit for Transcription Factor Binding To IGHM Enhancer 3 (TFE3)	CLIA assay for Antigen Detection
Assay Kits	ELO045Mu01	ELISA Kit for Transcription Factor Binding To IGHM Enhancer 3 (TFE3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPO045Ra01	Recombinant Transcription Factor Binding To IGHM Enhancer 3 (TFE3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAO045Ra01	Monoclonal Antibody to Transcription Factor Binding To IGHM Enhancer 3 (TFE3)	WB; IHC; ICC; IP.
Antibodies	PAO045Ra01	Polyclonal Antibody to Transcription Factor Binding To IGHM Enhancer 3 (TFE3)	WB; IHC; ICC; IF.
Assay Kits	CLO045Ra01	CLIA Kit for Transcription Factor Binding To IGHM Enhancer 3 (TFE3)	CLIA assay for Antigen Detection
Assay Kits	ELO045Ra01	ELISA Kit for Transcription Factor Binding To IGHM Enhancer 3 (TFE3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPO045Ca01	Recombinant Transcription Factor Binding To IGHM Enhancer 3 (TFE3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAO045Ca01	Monoclonal Antibody to Transcription Factor Binding To IGHM Enhancer 3 (TFE3)	WB; IHC; ICC; IP.
Antibodies	PAO045Ca01	Polyclonal Antibody to Transcription Factor Binding To IGHM Enhancer 3 (TFE3)	WB; IHC; ICC; IF.
Assay Kits	CLO045Ca01	CLIA Kit for Transcription Factor Binding To IGHM Enhancer 3 (TFE3)	CLIA assay for Antigen Detection
Assay Kits	ELO045Ca01	ELISA Kit for Transcription Factor Binding To IGHM Enhancer 3 (TFE3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPO045Po01	Recombinant Transcription Factor Binding To IGHM Enhancer 3 (TFE3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAO045Po01	Monoclonal Antibody to Transcription Factor Binding To IGHM Enhancer 3 (TFE3)	WB; IHC; ICC; IP.
Antibodies	PAO045Po01	Polyclonal Antibody to Transcription Factor Binding To IGHM Enhancer 3 (TFE3)	WB; IHC; ICC; IF.
Assay Kits	CLO045Po01	CLIA Kit for Transcription Factor Binding To IGHM Enhancer 3 (TFE3)	CLIA assay for Antigen Detection
Assay Kits	ELO045Po01	ELISA Kit for Transcription Factor Binding To IGHM Enhancer 3 (TFE3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPO045Bo01	Recombinant Transcription Factor Binding To IGHM Enhancer 3 (TFE3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAO045Bo01	Monoclonal Antibody to Transcription Factor Binding To IGHM Enhancer 3 (TFE3)	WB; IHC; ICC; IP.
Antibodies	PAO045Bo01	Polyclonal Antibody to Transcription Factor Binding To IGHM Enhancer 3 (TFE3)	WB; IHC; ICC; IF.
Assay Kits	CLO045Bo01	CLIA Kit for Transcription Factor Binding To IGHM Enhancer 3 (TFE3)	CLIA assay for Antigen Detection
Assay Kits	ELO045Bo01	ELISA Kit for Transcription Factor Binding To IGHM Enhancer 3 (TFE3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPO045Rb01	Recombinant Transcription Factor Binding To IGHM Enhancer 3 (TFE3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAO045Rb01	Monoclonal Antibody to Transcription Factor Binding To IGHM Enhancer 3 (TFE3)	WB; IHC; ICC; IP.
Antibodies	PAO045Rb01	Polyclonal Antibody to Transcription Factor Binding To IGHM Enhancer 3 (TFE3)	WB; IHC; ICC; IF.
Assay Kits	CLO045Rb01	CLIA Kit for Transcription Factor Binding To IGHM Enhancer 3 (TFE3)	CLIA assay for Antigen Detection
Assay Kits	ELO045Rb01	ELISA Kit for Transcription Factor Binding To IGHM Enhancer 3 (TFE3)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPO045Mo01	Recombinant Transcription Factor Binding To IGHM Enhancer 3 (TFE3)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAO045Mo01	Monoclonal Antibody to Transcription Factor Binding To IGHM Enhancer 3 (TFE3)	WB; IHC; ICC; IP.
Antibodies	PAO045Mo01	Polyclonal Antibody to Transcription Factor Binding To IGHM Enhancer 3 (TFE3)	WB; IHC; ICC; IF.
Assay Kits	CLO045Mo01	CLIA Kit for Transcription Factor Binding To IGHM Enhancer 3 (TFE3)	CLIA assay for Antigen Detection
Assay Kits	ELO045Mo01	ELISA Kit for Transcription Factor Binding To IGHM Enhancer 3 (TFE3)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Fusion of splicing factor genes PSF and NonO (p54nrb) to the TFE3 gene in papillary renal cell carcinoma."
Oncogene 15:2233-2239(1997) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of the human X chromosome."
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]

"Fusion of the transcription factor TFE3 gene to a novel gene, PRCC, in t(X;1)(p11;q21)-positive papillary renal cell carcinomas."
Proc. Natl. Acad. Sci. U.S.A. 93:15294-15298(1996) [PubMed] [Europe PMC] [Abstract]

"The t(X;1)(p11.2;q21.2) translocation in papillary renal cell carcinoma fuses a novel gene PRCC to the TFE3 transcription factor gene."
Hum. Mol. Genet. 5:1333-1338(1996) [PubMed] [Europe PMC] [Abstract]

"TFE3: a helix-loop-helix protein that activates transcription through the immunoglobulin enhancer muE3 motif."
Genes Dev. 4:167-179(1990) [PubMed] [Europe PMC] [Abstract]

"Fusion of a novel gene, RCC17, to the TFE3 gene in t(X;17)(p11.2;q25.3)-bearing papillary renal cell carcinomas."
Cancer Res. 61:4130-4135(2001) [PubMed] [Europe PMC] [Abstract]

"The der(17)t(X;17)(p11;q25) of human alveolar soft part sarcoma fuses the TFE3 transcription factor gene to ASPL, a novel gene at 17q25."
Oncogene 20:48-57(2001) [PubMed] [Europe PMC] [Abstract]

"Sumoylation of MITF and its related family members TFE3 and TFEB."
J. Biol. Chem. 280:146-155(2005) [PubMed] [Europe PMC] [Abstract]

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]