Succinate Dehydrogenase Complex Subunit B (SDHB)

SDH1; SDH; Ip; Iron Sulfur; Iron-sulfur subunit of complex II; Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

SPN	O010
HGNC	10681
MGI	1914930
PubMed	21934479
RGD	1308598
UniProt	P21912
Wiki	SDHB

Complex II in mitochondria, of which succinate dehydrogenase (EC 1.3.99.1) is a component, has 4 subunits. In order of decreasing molecular mass, they are the flavoprotein (SDHA), the iron sulfur protein (SDHB), and the 2 integral membrane proteins, SDHC and SDHD.

Kita et al. (1990) cloned and sequenced the iron sulfur protein subunit. A clone was isolated from a human liver cDNA library. The open reading frame encodes a 252-amino acid protein. The amino acid sequence showed approximately 94% homology with that of bovine heart. Au et al. (1995) described the complete genomic clone for the gene encoding the iron sulfur protein subunit.

Reference

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Erratum
Proc. Natl. Acad. Sci. U.S.A. 90:2556-2556(1993)

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma."
Am. J. Hum. Genet. 69:49-54(2001) [PubMed] [Europe PMC] [Abstract]

"Familial malignant catecholamine-secreting paraganglioma with prolonged survival associated with mutation in the succinate dehydrogenase B gene."
J. Clin. Endocrinol. Metab. 87:4101-4105(2002) [PubMed] [Europe PMC] [Abstract]

"Prevalence of SDHB, SDHC, and SDHD germline mutations in clinic patients with head and neck paragangliomas."
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"Germ-line mutations in nonsyndromic pheochromocytoma."
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"Mutations in the SDHB gene are associated with extra-adrenal and/or malignant phaeochromocytomas."
Cancer Res. 63:5615-5621(2003) [PubMed] [Europe PMC] [Abstract]

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"Novel succinate dehydrogenase subunit B (SDHB) mutations in familial phaeochromocytomas and paragangliomas, but an absence of somatic SDHB mutations in sporadic phaeochromocytomas."
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"K40E: a novel succinate dehydrogenase (SDH)B mutation causing familial phaeochromocytoma and paraganglioma."
Clin. Endocrinol. (Oxf.) 61:510-514(2004) [PubMed] [Europe PMC] [Abstract]

"Distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD gene mutations."
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Erratum
JAMA 292:1686-1686(2004)

"A novel succinate dehydrogenase subunit B gene mutation, H132P, causes familial malignant sympathetic extraadrenal paragangliomas."
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"Somatic SDHB mutation in an extraadrenal pheochromocytoma."
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