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NADH Dehydrogenase Ubiquinone Fe-S Protein 1 (NDUFS1)

CI-75Kd; NADH-Coenzyme Q Reductase; NADH Dehydrogenase Iron-Sulfur Protein 1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

NDUFS1 belongs to the complex I 75 kDa subunit family. Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. This protein is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized. Mutations in this gene are associated with complex I deficiency.The predicted 727-amino acid human 75-kD Fe-S protein contains a 23-amino acid presequence and is 97% identical to the bovine homolog. Various cysteine-rich motifs similar to those found in rubredoxins, the Reiske Fe-S protein in Neurospora, and 4 Fe-4S ferredoxins are present in the protein sequence.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPN971Hu01 Recombinant NADH Dehydrogenase Ubiquinone Fe-S Protein 1 (NDUFS1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAN971Hu01 Monoclonal Antibody to NADH Dehydrogenase Ubiquinone Fe-S Protein 1 (NDUFS1) WB; IHC; ICC; IP.
PAN971Hu01 Polyclonal Antibody to NADH Dehydrogenase Ubiquinone Fe-S Protein 1 (NDUFS1) WB; IHC; ICC; IF.
Assay Kits CLN971Hu01 CLIA Kit for NADH Dehydrogenase Ubiquinone Fe-S Protein 1 (NDUFS1) CLIA assay for Antigen Detection
ELN971Hu01 ELISA Kit for NADH Dehydrogenase Ubiquinone Fe-S Protein 1 (NDUFS1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPN971Mu01 Recombinant NADH Dehydrogenase Ubiquinone Fe-S Protein 1 (NDUFS1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAN971Mu01 Monoclonal Antibody to NADH Dehydrogenase Ubiquinone Fe-S Protein 1 (NDUFS1) WB; IHC; ICC; IP.
PAN971Mu01 Polyclonal Antibody to NADH Dehydrogenase Ubiquinone Fe-S Protein 1 (NDUFS1) WB; IHC; ICC; IF.
Assay Kits CLN971Mu01 CLIA Kit for NADH Dehydrogenase Ubiquinone Fe-S Protein 1 (NDUFS1) CLIA assay for Antigen Detection
ELN971Mu01 ELISA Kit for NADH Dehydrogenase Ubiquinone Fe-S Protein 1 (NDUFS1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPN971Ra01 Recombinant NADH Dehydrogenase Ubiquinone Fe-S Protein 1 (NDUFS1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAN971Ra01 Monoclonal Antibody to NADH Dehydrogenase Ubiquinone Fe-S Protein 1 (NDUFS1) WB; IHC; ICC; IP.
PAN971Ra01 Polyclonal Antibody to NADH Dehydrogenase Ubiquinone Fe-S Protein 1 (NDUFS1) WB; IHC; ICC; IF.
Assay Kits CLN971Ra01 CLIA Kit for NADH Dehydrogenase Ubiquinone Fe-S Protein 1 (NDUFS1) CLIA assay for Antigen Detection
ELN971Ra01 ELISA Kit for NADH Dehydrogenase Ubiquinone Fe-S Protein 1 (NDUFS1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPN971Ca01 Recombinant NADH Dehydrogenase Ubiquinone Fe-S Protein 1 (NDUFS1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAN971Ca01 Monoclonal Antibody to NADH Dehydrogenase Ubiquinone Fe-S Protein 1 (NDUFS1) WB; IHC; ICC; IP.
PAN971Ca01 Polyclonal Antibody to NADH Dehydrogenase Ubiquinone Fe-S Protein 1 (NDUFS1) WB; IHC; ICC; IF.
Assay Kits CLN971Ca01 CLIA Kit for NADH Dehydrogenase Ubiquinone Fe-S Protein 1 (NDUFS1) CLIA assay for Antigen Detection
ELN971Ca01 ELISA Kit for NADH Dehydrogenase Ubiquinone Fe-S Protein 1 (NDUFS1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPN971Po01 Recombinant NADH Dehydrogenase Ubiquinone Fe-S Protein 1 (NDUFS1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAN971Po01 Monoclonal Antibody to NADH Dehydrogenase Ubiquinone Fe-S Protein 1 (NDUFS1) WB; IHC; ICC; IP.
PAN971Po01 Polyclonal Antibody to NADH Dehydrogenase Ubiquinone Fe-S Protein 1 (NDUFS1) WB; IHC; ICC; IF.
Assay Kits CLN971Po01 CLIA Kit for NADH Dehydrogenase Ubiquinone Fe-S Protein 1 (NDUFS1) CLIA assay for Antigen Detection
ELN971Po01 ELISA Kit for NADH Dehydrogenase Ubiquinone Fe-S Protein 1 (NDUFS1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPN971Bo01 Recombinant NADH Dehydrogenase Ubiquinone Fe-S Protein 1 (NDUFS1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAN971Bo01 Monoclonal Antibody to NADH Dehydrogenase Ubiquinone Fe-S Protein 1 (NDUFS1) WB; IHC; ICC; IP.
PAN971Bo01 Polyclonal Antibody to NADH Dehydrogenase Ubiquinone Fe-S Protein 1 (NDUFS1) WB; IHC; ICC; IF.
Assay Kits CLN971Bo01 CLIA Kit for NADH Dehydrogenase Ubiquinone Fe-S Protein 1 (NDUFS1) CLIA assay for Antigen Detection
ELN971Bo01 ELISA Kit for NADH Dehydrogenase Ubiquinone Fe-S Protein 1 (NDUFS1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPN971Rb01 Recombinant NADH Dehydrogenase Ubiquinone Fe-S Protein 1 (NDUFS1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAN971Rb01 Monoclonal Antibody to NADH Dehydrogenase Ubiquinone Fe-S Protein 1 (NDUFS1) WB; IHC; ICC; IP.
PAN971Rb01 Polyclonal Antibody to NADH Dehydrogenase Ubiquinone Fe-S Protein 1 (NDUFS1) WB; IHC; ICC; IF.
Assay Kits CLN971Rb01 CLIA Kit for NADH Dehydrogenase Ubiquinone Fe-S Protein 1 (NDUFS1) CLIA assay for Antigen Detection
ELN971Rb01 ELISA Kit for NADH Dehydrogenase Ubiquinone Fe-S Protein 1 (NDUFS1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPN971Mo01 Recombinant NADH Dehydrogenase Ubiquinone Fe-S Protein 1 (NDUFS1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAN971Mo01 Monoclonal Antibody to NADH Dehydrogenase Ubiquinone Fe-S Protein 1 (NDUFS1) WB; IHC; ICC; IP.
PAN971Mo01 Polyclonal Antibody to NADH Dehydrogenase Ubiquinone Fe-S Protein 1 (NDUFS1) WB; IHC; ICC; IF.
Assay Kits CLN971Mo01 CLIA Kit for NADH Dehydrogenase Ubiquinone Fe-S Protein 1 (NDUFS1) CLIA assay for Antigen Detection
ELN971Mo01 ELISA Kit for NADH Dehydrogenase Ubiquinone Fe-S Protein 1 (NDUFS1) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Determination of the cDNA sequence for the human mitochondrial 75-kDa Fe-S protein of NADH-coenzyme Q reductase."
Eur. J. Biochem. 201:547-550(1991) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

, Submitted (DEC-2008) to UniProtKB

"The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification."
J. Biol. Chem. 278:13619-13622(2003) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Large-scale deletion and point mutations of the nuclear NDUFV1 and NDUFS1 genes in mitochondrial complex I deficiency."
Am. J. Hum. Genet. 68:1344-1352(2001) [PubMed] [Europe PMC] [Abstract]

"Genomic analysis of mitochondrial diseases in a consanguineous population reveals novel candidate disease genes."
J. Med. Genet. 49:234-241(2012) [PubMed] [Europe PMC] [Abstract]