Phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1)
BCAP; B-cell adapter for phosphoinositide 3-kinase; B-cell phosphoinositide 3-kinase adapter protein 1
Using an affinity purification strategy with the N-terminal SH2 domain of the phosphoinositide 3-kinase (PI3K) p85 subunit and anti-phosphotyrosine antibody, followed by screening a chicken DT40 B-cell cDNA library and a mouse spleen cDNA library, Okada et al. (2000) isolated cDNAs encoding chicken and mouse Pik3ap1, which they called Bcap. They also identified Bcap splice variants. Northern blot analysis of mouse tissues detected expression predominantly in spleen, with lower levels in thymus, liver, and lung. Expression was also detected in mouse macrophage and B-cell lines, but not in T-cell, plasma cell, or mast cell lines.Using mouse and chicken B- cell lines, Okada et al. (2000) determined that Bcap is a protein tyrosine kinase substrate that couples B-cell receptor to PI3K activation.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN929Hu01 | Recombinant Phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN929Hu01 | Monoclonal Antibody to Phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) | WB; IHC; ICC; IP. |
| PAN929Hu01 | Polyclonal Antibody to Phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN929Hu01 | CLIA Kit for Phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) | CLIA assay for Antigen Detection |
| ELN929Hu01 | ELISA Kit for Phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN929Mu01 | Recombinant Phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN929Mu01 | Monoclonal Antibody to Phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) | WB; IHC; ICC; IP. |
| PAN929Mu01 | Polyclonal Antibody to Phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN929Mu01 | CLIA Kit for Phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) | CLIA assay for Antigen Detection |
| ELN929Mu01 | ELISA Kit for Phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN929Ra01 | Recombinant Phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN929Ra01 | Monoclonal Antibody to Phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) | WB; IHC; ICC; IP. |
| PAN929Ra01 | Polyclonal Antibody to Phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN929Ra01 | CLIA Kit for Phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) | CLIA assay for Antigen Detection |
| ELN929Ra01 | ELISA Kit for Phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN929Ca01 | Recombinant Phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN929Ca01 | Monoclonal Antibody to Phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) | WB; IHC; ICC; IP. |
| PAN929Ca01 | Polyclonal Antibody to Phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN929Ca01 | CLIA Kit for Phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) | CLIA assay for Antigen Detection |
| ELN929Ca01 | ELISA Kit for Phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN929Po01 | Recombinant Phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN929Po01 | Monoclonal Antibody to Phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) | WB; IHC; ICC; IP. |
| PAN929Po01 | Polyclonal Antibody to Phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN929Po01 | CLIA Kit for Phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) | CLIA assay for Antigen Detection |
| ELN929Po01 | ELISA Kit for Phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN929Bo01 | Recombinant Phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN929Bo01 | Monoclonal Antibody to Phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) | WB; IHC; ICC; IP. |
| PAN929Bo01 | Polyclonal Antibody to Phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN929Bo01 | CLIA Kit for Phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) | CLIA assay for Antigen Detection |
| ELN929Bo01 | ELISA Kit for Phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN929Rb01 | Recombinant Phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN929Rb01 | Monoclonal Antibody to Phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) | WB; IHC; ICC; IP. |
| PAN929Rb01 | Polyclonal Antibody to Phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN929Rb01 | CLIA Kit for Phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) | CLIA assay for Antigen Detection |
| ELN929Rb01 | ELISA Kit for Phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN929Mo01 | Recombinant Phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN929Mo01 | Monoclonal Antibody to Phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) | WB; IHC; ICC; IP. |
| PAN929Mo01 | Polyclonal Antibody to Phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN929Mo01 | CLIA Kit for Phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) | CLIA assay for Antigen Detection |
| ELN929Mo01 | ELISA Kit for Phosphoinositide-3-Kinase Adaptor Protein 1 (PIK3AP1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and comparative analysis of human chromosome 10."
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Identification of B cell adaptor for PI3-kinase (BCAP) as an Abl interactor 1-regulated substrate of Abl kinases."
FEBS Lett. 579:2986-2990(2005) [PubMed] [Europe PMC] [Abstract]
"Enhanced NK cell development and function in BCAP-deficient mice."
Blood 112:131-140(2008) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]