Jumping Translocation Breakpoint Protein (JTB)

PAR; B PAR; HJTB; hJT; Prostate Androgen-Regulated Gene

SPN	N890
HGNC	6201
MGI	1346082
PubMed	10321732
RGD	2942
UniProt	O76095
Wiki	JTB

The JTB open reading frame encodes a 146-amino acid protein with a 75-amino acid extracellular domain (after removal of the signal sequence), a 21-amino acid transmembrane domain, and a 20-amino acid intracellular domain.

The JTB protein is highly conserved among divergent eukaryotic species. Northern blot analysis showed ubiquitous expression of a 1-kb mRNA, with highest expression in thyroid and skeletal muscle. Kidney and spinal cord expressed an additional transcript of approximately 1.4 kb. The JTB gene contains 5 exons over a length of 3 kb. The jumping translocation resulted in a JTB truncation, which would potentially produce a JTB product devoid of the transmembrane domain. JTB is located in a gene-rich region at 1q21, called the epidermal differentiation complex (EDC).

Reference

"JTB: a novel membrane protein gene at 1q21 rearranged in a jumping translocation."
Oncogene 18:2085-2090(1999) [PubMed] [Europe PMC] [Abstract]

"PAR, a novel androgen regulated gene, ubiquitously expressed in normal and malignant cells."
Int. J. Oncol. 16:1055-1061(2000) [PubMed] [Europe PMC] [Abstract]

"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Characterization of Jumping translocation breakpoint (JTB) gene product isolated as a TGF-beta1-inducible clone involved in regulation of mitochondrial function, cell growth and cell death."
Oncogene 26:5991-6001(2007) [PubMed] [Europe PMC] [Abstract]

"PAR, a protein involved in the cell cycle, is functionally related to chromosomal passenger proteins."
Int. J. Oncol. 38:777-785(2011) [PubMed] [Europe PMC] [Abstract]

"The structure of the extracellular domain of the jumping translocation breakpoint protein reveals a variation of the midkine fold."
J. Mol. Biol. 415:22-28(2012) [PubMed] [Europe PMC] [Abstract]