Ras Association Domain Containing Protein 1 (RASSF1)

123F2; NORE2A; RASSF1A; RDA32; REH3P21

SPN	N832
HGNC	9882
MGI	1928386
PubMed	19795445
RGD	1359383
UniProt	Q9NS23
Wiki	RASSF1

RASSF1 encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest.

Isoform A and isoform C are ubiquitously expressed in all tissues tested, however isoform A is absent in many corresponding cancer cell lines. Isoform B is mainly expressed in hematopoetic cells.

Reference

"Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3."
Nat. Genet. 25:315-319(2000) [PubMed] [Europe PMC] [Abstract]

"Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression."
J. Natl. Cancer Inst. 93:691-699(2001) [PubMed] [Europe PMC] [Abstract], Lung and Pancreas.

"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation."
Mol. Cell. Biol. 22:4309-4318(2002) [PubMed] [Europe PMC] [Abstract]

"The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1."
Oncogene 21:1381-1390(2002) [PubMed] [Europe PMC] [Abstract]

Erratum
Oncogene 21:1943-1943(2002)

"Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene."
Cancer Res. 64:102-107(2004) [PubMed] [Europe PMC] [Abstract]

"RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics."
Cancer Res. 64:4112-4116(2004) [PubMed] [Europe PMC] [Abstract]

"The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex."
Nat. Cell Biol. 6:129-137(2004) [PubMed] [Europe PMC] [Abstract]

"Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras."
Biochem. J. 381:453-462(2004) [PubMed] [Europe PMC] [Abstract]

"Specificity of the methylation-suppressed A isoform of candidate tumor suppressor RASSF1 for microtubule hyperstabilization is determined by cell death inducer C19ORF5."
Cancer Res. 65:1830-1838(2005) [PubMed] [Europe PMC] [Abstract]

"The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational change and cell death."
Mol. Cell 18:637-650(2005) [PubMed] [Europe PMC] [Abstract]

"Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis."
Cancer Res. 66:2562-2569(2006) [PubMed] [Europe PMC] [Abstract]

"The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex."
EMBO J. 27:1863-1874(2008) [PubMed] [Europe PMC] [Abstract]

"Large-scale proteomics analysis of the human kinome."
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

"The tumor suppressor RASSF1A prevents dephosphorylation of the mammalian STE20-like kinases MST1 and MST2."
J. Biol. Chem. 286:6253-6261(2011) [PubMed] [Europe PMC] [Abstract]

"Structural characterization of the DAXX N-terminal helical bundle domain and its complex with Rassf1C."
Structure 18:1642-1653(2010) [PubMed] [Europe PMC] [Abstract]