ISL LIM Homeobox Protein 1 (ISL1)

Islet-1; ISL1 Transcription Factor,LIM/Homeodomain; Insulin gene enhancer protein ISL-1

SPN	N774
HGNC	6132
MGI	101791
PubMed	23436614
RGD	61957
UniProt	P61371
Wiki	ISL1

ISL1encodes a transcription factor containing two N-terminal LIM domains and one C-terminal homeodomain. The encoded protein plays an important role in the embryogenesis of pancreatic islets of Langerhans. In mouse embryos, a deficiency of this gene fail to undergo neural tube motor neuron differentiation.

ISL1 is a marker for cardiac progenitors of the secondary heart field (SHF) which includes the right ventricle and the outflow tract. It also has a biological function as shown in Isl1 knockout mice which have a severely deformed heart. More recently it has been defined as a marker for a cardiac progenitor cell lineage that is capable of differentiating into all 3 major cell types of the heart: Cardiomyocytes, smooth muscle and endothelial cell lineages.

Reference

"The LIM domain homeobox gene isl-1: conservation of human, hamster, and rat complementary deoxyribonucleic acid sequences and expression in cell types of nonneuroendocrine lineage."
Endocrinology 134:1416-1422(1994) [PubMed] [Europe PMC] [Abstract]

"Isolation of the human LIM/homeodomain gene islet-1 and identification of a simple sequence repeat polymorphism."
Diabetes 43:935-941(1994) [PubMed] [Europe PMC] [Abstract]

Erratum
Diabetes 43:1171-1171(1994)

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Phosphoproteome of resting human platelets."
J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]