Necdin (NDN)

PWCR; Necdin Homolog

SPN	N682
HGNC	7675
MGI	97290
PubMed	22776820
RGD	1310526
UniProt	Q99608
Wiki	NDN

Necdin is located in the Prader-Willi syndrome (PWS) deletion region. It is an imprinted gene and is expressed exclusively from the paternal allele. Studies in mouse suggest that the protein encoded by this gene may suppress growth in postmitotic neurons. An EST showed 99% sequence identity to the 3-prime end of a GenBank sequence, defined as 'a human necdin-related protein mRNA.' Mouse necdin (Ndn) was originally identified as a protein encoded by a neural differentiation-specific mRNA, derived from embryonal carcinoma cells.

The necdin protein was localized to the nuclei of postmitotic neurons and was expressed in almost all postmitotic neurons in the CNS from the beginning of neural differentiation and into adult life.

Reference

"The human necdin gene, NDN, is maternally imprinted and located in the Prader-Willi syndrome chromosomal region."
Nat. Genet. 17:357-360(1997) [PubMed] [Europe PMC] [Abstract]

"The human chromosomal gene for necdin, a neuronal growth suppressor, in the Prader-Willi syndrome deletion region."
Gene 213:65-72(1998) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Mutational analysis of the necdin gene in patients with congenital isolated hypogonadotropic hypogonadism."
Eur. J. Endocrinol. 165:145-150(2011) [PubMed] [Europe PMC] [Abstract]