A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4)
ADMP-1; Aggrecanase-1
ADAMTS4 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN528Hu01 | Recombinant A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN528Hu01 | Monoclonal Antibody to A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) | WB; IHC; ICC; IP. |
| PAN528Hu01 | Polyclonal Antibody to A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN528Hu01 | CLIA Kit for A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) | CLIA assay for Antigen Detection |
| ELN528Hu01 | ELISA Kit for A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN528Mu01 | Recombinant A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN528Mu01 | Monoclonal Antibody to A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) | WB; IHC; ICC; IP. |
| PAN528Mu01 | Polyclonal Antibody to A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN528Mu01 | CLIA Kit for A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) | CLIA assay for Antigen Detection |
| ELN528Mu01 | ELISA Kit for A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN528Ra01 | Recombinant A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN528Ra01 | Monoclonal Antibody to A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) | WB; IHC; ICC; IP. |
| PAN528Ra01 | Polyclonal Antibody to A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN528Ra01 | CLIA Kit for A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) | CLIA assay for Antigen Detection |
| ELN528Ra01 | ELISA Kit for A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN528Ca01 | Recombinant A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN528Ca01 | Monoclonal Antibody to A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) | WB; IHC; ICC; IP. |
| PAN528Ca01 | Polyclonal Antibody to A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN528Ca01 | CLIA Kit for A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) | CLIA assay for Antigen Detection |
| ELN528Ca01 | ELISA Kit for A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN528Po01 | Recombinant A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN528Po01 | Monoclonal Antibody to A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) | WB; IHC; ICC; IP. |
| PAN528Po01 | Polyclonal Antibody to A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN528Po01 | CLIA Kit for A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) | CLIA assay for Antigen Detection |
| ELN528Po01 | ELISA Kit for A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN528Bo01 | Recombinant A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN528Bo01 | Monoclonal Antibody to A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) | WB; IHC; ICC; IP. |
| PAN528Bo01 | Polyclonal Antibody to A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN528Bo01 | CLIA Kit for A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) | CLIA assay for Antigen Detection |
| ELN528Bo01 | ELISA Kit for A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN528Rb01 | Recombinant A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN528Rb01 | Monoclonal Antibody to A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) | WB; IHC; ICC; IP. |
| PAN528Rb01 | Polyclonal Antibody to A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN528Rb01 | CLIA Kit for A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) | CLIA assay for Antigen Detection |
| ELN528Rb01 | ELISA Kit for A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN528Mo01 | Recombinant A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN528Mo01 | Monoclonal Antibody to A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) | WB; IHC; ICC; IP. |
| PAN528Mo01 | Polyclonal Antibody to A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN528Mo01 | CLIA Kit for A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) | CLIA assay for Antigen Detection |
| ELN528Mo01 | ELISA Kit for A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins."
Science 284:1664-1666(1999) [PubMed] [Europe PMC] [Abstract]
"An alternative spliced transcript of ADAMTS4 is present in human synovium from OA patients."
Matrix Biol. 25:317-320(2006) [PubMed] [Europe PMC] [Abstract]
"Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"The thrombospondin motif of aggrecanase-1 (ADAMTS-4) is critical for aggrecan substrate recognition and cleavage."
J. Biol. Chem. 275:25791-25797(2000) [PubMed] [Europe PMC] [Abstract]
"Epileptic and developmental disorders of the speech cortex: ligand/receptor interaction of wild-type and mutant SRPX2 with the plasminogen activator receptor uPAR."
Hum. Mol. Genet. 17:3617-3630(2008) [PubMed] [Europe PMC] [Abstract]
"ADAMTS-4_v1 is a splice variant of ADAMTS-4 that is expressed as a protein in human synovium and cleaves aggrecan at the interglobular domain."
Arthritis Rheum. 65:2866-2875(2013) [PubMed] [Europe PMC] [Abstract]
"Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5."
Protein Sci. 17:16-21(2008) [PubMed] [Europe PMC] [Abstract]