Succinate Dehydrogenase Complex Subunit C (SDHC)
PGL3; CYB560, SDH3; CYBL; QPs1; Integral membrane protein CII-3; Succinate-ubiquinone oxidoreductase cytochrome B large subunit; Succinate dehydrogenase cytochrome b560
SDHC encodes one of four nuclear-encoded subunits that comprise succinate dehydrogenase, also known as mitochondrial complex II, a key enzyme complex of the tricarboxylic acid cycle and aerobic respiratory chains of mitochondria.
The encoded protein is one of two integral membrane proteins that anchor other subunits of the complex, which form the catalytic core, to the inner mitochondrial membrane. Several related pseudogenes are located in different genomic regions. Mutations in this gene have been associated with paragangliomas. Alternatively spliced transcript variants encoding different isoforms have been described.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN519Hu01 | Recombinant Succinate Dehydrogenase Complex Subunit C (SDHC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN519Hu01 | Monoclonal Antibody to Succinate Dehydrogenase Complex Subunit C (SDHC) | WB; IHC; ICC; IP. |
| PAN519Hu01 | Polyclonal Antibody to Succinate Dehydrogenase Complex Subunit C (SDHC) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN519Hu01 | CLIA Kit for Succinate Dehydrogenase Complex Subunit C (SDHC) | CLIA assay for Antigen Detection |
| ELN519Hu01 | ELISA Kit for Succinate Dehydrogenase Complex Subunit C (SDHC) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN519Mu01 | Recombinant Succinate Dehydrogenase Complex Subunit C (SDHC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN519Mu01 | Monoclonal Antibody to Succinate Dehydrogenase Complex Subunit C (SDHC) | WB; IHC; ICC; IP. |
| PAN519Mu01 | Polyclonal Antibody to Succinate Dehydrogenase Complex Subunit C (SDHC) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN519Mu01 | CLIA Kit for Succinate Dehydrogenase Complex Subunit C (SDHC) | CLIA assay for Antigen Detection |
| ELN519Mu01 | ELISA Kit for Succinate Dehydrogenase Complex Subunit C (SDHC) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN519Ra01 | Recombinant Succinate Dehydrogenase Complex Subunit C (SDHC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN519Ra01 | Monoclonal Antibody to Succinate Dehydrogenase Complex Subunit C (SDHC) | WB; IHC; ICC; IP. |
| PAN519Ra01 | Polyclonal Antibody to Succinate Dehydrogenase Complex Subunit C (SDHC) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN519Ra01 | CLIA Kit for Succinate Dehydrogenase Complex Subunit C (SDHC) | CLIA assay for Antigen Detection |
| ELN519Ra01 | ELISA Kit for Succinate Dehydrogenase Complex Subunit C (SDHC) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN519Ca01 | Recombinant Succinate Dehydrogenase Complex Subunit C (SDHC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN519Ca01 | Monoclonal Antibody to Succinate Dehydrogenase Complex Subunit C (SDHC) | WB; IHC; ICC; IP. |
| PAN519Ca01 | Polyclonal Antibody to Succinate Dehydrogenase Complex Subunit C (SDHC) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN519Ca01 | CLIA Kit for Succinate Dehydrogenase Complex Subunit C (SDHC) | CLIA assay for Antigen Detection |
| ELN519Ca01 | ELISA Kit for Succinate Dehydrogenase Complex Subunit C (SDHC) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN519Po01 | Recombinant Succinate Dehydrogenase Complex Subunit C (SDHC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN519Po01 | Monoclonal Antibody to Succinate Dehydrogenase Complex Subunit C (SDHC) | WB; IHC; ICC; IP. |
| PAN519Po01 | Polyclonal Antibody to Succinate Dehydrogenase Complex Subunit C (SDHC) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN519Po01 | CLIA Kit for Succinate Dehydrogenase Complex Subunit C (SDHC) | CLIA assay for Antigen Detection |
| ELN519Po01 | ELISA Kit for Succinate Dehydrogenase Complex Subunit C (SDHC) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN519Bo01 | Recombinant Succinate Dehydrogenase Complex Subunit C (SDHC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN519Bo01 | Monoclonal Antibody to Succinate Dehydrogenase Complex Subunit C (SDHC) | WB; IHC; ICC; IP. |
| PAN519Bo01 | Polyclonal Antibody to Succinate Dehydrogenase Complex Subunit C (SDHC) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN519Bo01 | CLIA Kit for Succinate Dehydrogenase Complex Subunit C (SDHC) | CLIA assay for Antigen Detection |
| ELN519Bo01 | ELISA Kit for Succinate Dehydrogenase Complex Subunit C (SDHC) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN519Rb01 | Recombinant Succinate Dehydrogenase Complex Subunit C (SDHC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN519Rb01 | Monoclonal Antibody to Succinate Dehydrogenase Complex Subunit C (SDHC) | WB; IHC; ICC; IP. |
| PAN519Rb01 | Polyclonal Antibody to Succinate Dehydrogenase Complex Subunit C (SDHC) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN519Rb01 | CLIA Kit for Succinate Dehydrogenase Complex Subunit C (SDHC) | CLIA assay for Antigen Detection |
| ELN519Rb01 | ELISA Kit for Succinate Dehydrogenase Complex Subunit C (SDHC) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPN519Mo01 | Recombinant Succinate Dehydrogenase Complex Subunit C (SDHC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAN519Mo01 | Monoclonal Antibody to Succinate Dehydrogenase Complex Subunit C (SDHC) | WB; IHC; ICC; IP. |
| PAN519Mo01 | Polyclonal Antibody to Succinate Dehydrogenase Complex Subunit C (SDHC) | WB; IHC; ICC; IF. | |
| Assay Kits | CLN519Mo01 | CLIA Kit for Succinate Dehydrogenase Complex Subunit C (SDHC) | CLIA assay for Antigen Detection |
| ELN519Mo01 | ELISA Kit for Succinate Dehydrogenase Complex Subunit C (SDHC) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Cytochrome b in human complex II (succinate-ubiquinone oxidoreductase): cDNA cloning of the components in liver mitochondria and chromosome assignment of the genes for the large (SDHC) and small (SDHD) subunits to 1q21 and 11q23."
Cytogenet. Cell Genet. 79:132-138(1997) [PubMed] [Europe PMC] [Abstract]
"Characterization of the human SDHC gene encoding one of the integral membrane proteins of succinate-quinone oxidoreductase in mitochondria."
Gene 213:133-140(1998) [PubMed] [Europe PMC] [Abstract]
"A human succinate-ubiquinone oxidoreductase CII-3 subunit gene ending in a polymorphic dinucleotide repeat is located within the sulfonylurea receptor (SUR) gene."
Mol. Genet. Metab. 65:187-190(1998) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Mutations in SDHC cause autosomal dominant paraganglioma, type 3."
Nat. Genet. 26:268-270(2000) [PubMed] [Europe PMC] [Abstract]
"Familial gastrointestinal stromal tumors and germ-line mutations."
N. Engl. J. Med. 357:1054-1056(2007) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]