A Disintegrin And Metalloprotease 19 (ADAM19)

FKSG34; MADDAM; MLTNB; meltrin beta; Metalloprotease and disintegrin dendritic antigen marker; Disintegrin and metalloproteinase domain-containing protein 19

SPN	N492
HGNC	197
MGI	105377
PubMed	23429442
RGD	1585017
UniProt	Q9H013
Wiki	ADAM19

ADAM19 encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis.This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has also been demonstrated to be an active metalloproteinase, which may be involved in normal physiological and pathological processes such as cells migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. Alternative splicing results in two transcript variants.

Reference

"Molecular cloning and characterization of a human metalloprotease disintegrin a novel marker for dendritic cell differentiation."
Blood 96:732-739(2000) [PubMed] [Europe PMC] [Abstract]

"Expression and enzymatic activity of human disintegrin and metalloproteinase ADAM19/meltrin beta."
Biochem. Biophys. Res. Commun. 280:744-755(2001) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 5."
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]

"The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells."
J. Biol. Chem. 278:16844-16851(2003) [PubMed] [Europe PMC] [Abstract]

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

"Core signaling pathways in human pancreatic cancers revealed by global genomic analyses."
Science 321:1801-1806(2008) [PubMed] [Europe PMC] [Abstract]